Compound
thiamine(1+) diphosphate
A thiamine phosphate that is thiamine(1+) in which the hydroxy group has been replaced by a diphosphate group. It is the active form of vitamin B1 and an essential cofactor for enzymes in key metabolic pathways.
Definition from ChEBI (CHEBI:9532), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- BCKDHAProteinUNIPROT:P12694substrate ofInferred only76 paths19 endpoints
- BCKDHBProteinUNIPROT:P21953substrate ofInferred only64 paths16 endpoints
- PDHA1ProteinUNIPROT:P08559substrate ofInferred only38 paths38 endpoints
- OGDHProteinUNIPROT:Q02218substrate ofInferred only36 paths18 endpoints
- PDHBProteinUNIPROT:P11177substrate ofInferred only21 paths21 endpoints
- PDHA2ProteinUNIPROT:P29803substrate ofInferred only15 paths15 endpoints
- DHTKD1ProteinUNIPROT:Q96HY7substrate ofInferred only14 paths7 endpoints
- TPK1ProteinUNIPROT:Q9H3S4substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
23 statements
23 statements · 1 reference database · Subject: thiamine(1+) diphosphate · Sources: Human-GEM
- thiamine is converted to thiamine(1+) diphosphateCompoundHuman-GEM MAR04204Inferred only
- thiamine(1+) diphosphate is converted to thiamine triphosphateCompoundHuman-GEM MAR04206Inferred only
- thiamine triphosphate is converted to thiamine(1+) diphosphateCompoundHuman-GEM MAR04207Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR03800Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR20176Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR20174Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR20175Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR20174Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR03800Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR20176Inferred only
- thiamine(1+) diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR20175Inferred only
- thiamine(1+) diphosphate is a substrate of DHTKD1ProteinHuman-GEM MAR04209Inferred only
Show the remaining 11
- thiamine(1+) diphosphate is a substrate of DHTKD1ProteinHuman-GEM MAR20173Inferred only
- thiamine(1+) diphosphate is a substrate of NTPCRProteinHuman-GEM MAR04208Inferred only
- thiamine(1+) diphosphate is a substrate of NTPCRProteinHuman-GEM MAR08744Inferred only
- thiamine(1+) diphosphate is a substrate of OGDHProteinHuman-GEM MAR20173Inferred only
- thiamine(1+) diphosphate is a substrate of OGDHProteinHuman-GEM MAR04209Inferred only
- thiamine(1+) diphosphate is a substrate of PDHA1ProteinHuman-GEM MAR08746Inferred only
- thiamine(1+) diphosphate is a substrate of PDHA2ProteinHuman-GEM MAR08746Inferred only
- thiamine(1+) diphosphate is a substrate of PDHBProteinHuman-GEM MAR08746Inferred only
- thiamine(1+) diphosphate is a substrate of TPK1ProteinHuman-GEM MAR04206Inferred only
- thiamine(1+) diphosphate is transported by SLC25A19ProteinHuman-GEM MAR20183Inferred only
- thiamine(1+) diphosphate is transported by SLC25A19ProteinHuman-GEM MAR20181Inferred only
Reactions
22 reactions
2-oxobutanoate+proton+thiamine(1+) diphosphatecarbon dioxide+2-(alpha-Hydroxypropyl)thiamine diphosphate
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4mitochondrial matrix
Human-GEM MAR03800CC BY 4.0Reference data
ATP+thiamineAMP+proton+thiamine(1+) diphosphate
Catalysed by TPK1
Reaction pageLeft to rightBalancedEC 2.7.6.2cytosol
Human-GEM MAR04204CC BY 4.0Reference data
ATP+thiamine(1+) diphosphateADP+thiamine triphosphate
Catalysed by TPK1
Reaction pageLeft to rightBalancedEC 2.7.6.2cytosol
Human-GEM MAR04206CC BY 4.0Reference data
water+thiamine triphosphateproton+phosphate(3-)+thiamine(1+) diphosphate
Catalysed by THTPA
Reaction pageLeft to rightBalancedEC 3.6.1.28cytosol
Human-GEM MAR04207CC BY 4.0Reference data
water+thiamine(1+) diphosphateproton+phosphate(3-)+MAM02983c
Catalysed by NTPCR
Reaction pageLeft to rightBalancedEC 3.6.1.15cytosol
Human-GEM MAR04208CC BY 4.0Reference data
2-oxoglutarate(2-)+proton+thiamine(1+) diphosphateMAM00765m+carbon dioxide
Reaction pageLeft to rightBalancedEC 1.2.4.2mitochondrial matrix
Human-GEM MAR04209CC BY 4.0Reference data
MAM02393m+MAM20077mMAM02899m+thiamine(1+) diphosphate
Catalysed by DLST & OGDH or DLST & DHTKD1
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.2mitochondrial matrix
Human-GEM MAR04599CC BY 4.0Reference data
MAM00765m+MAM02393mMAM02934m+thiamine(1+) diphosphate
Reaction pageLeft to rightBalancedEC 1.2.4.2mitochondrial matrix
Human-GEM MAR06413CC BY 4.0Reference data
MAM02393m+2-methyl-1-hydroxypropylthiamine diphosphateMAM02857m+thiamine(1+) diphosphate
Catalysed by DBT & BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4mitochondrial matrix
Human-GEM MAR06416CC BY 4.0Reference data
MAM02393m+MAM20079mMAM02856m+thiamine(1+) diphosphate
Catalysed by DBT & BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4mitochondrial matrix
Human-GEM MAR06419CC BY 4.0Reference data
MAM02393m+3-methyl-1-hydroxybutylthiamine diphosphateMAM02858m+thiamine(1+) diphosphate
Catalysed by DBT & BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4mitochondrial matrix
Human-GEM MAR06421CC BY 4.0Reference data
water+thiamine(1+) diphosphateproton+phosphate(3-)+MAM02983m
Catalysed by NTPCR
Reaction pageLeft to rightBalancedEC 3.6.1.15mitochondrial matrix
Human-GEM MAR08744CC BY 4.0Reference data
On the label
Labelled products
5 products
Source: NIH DSLD · Ingredient: thiamine(1+) diphosphate · 5 products · Declared amount per serving: 1–2 mg (5 products)
5 labels state an amount0 do not
- Nutri-WestBiostress-BThiamine Pyrophosphate Note: coenzyme1 mgper 1 Tablet(s)DSLD:27554
- Nutri-WestBiostress-BThiamine Pyrophosphate Note: coenzyme1 mgper 1 Tablet(s)DSLD:27555
- Nutri-WestCardioplexCocarboxylase1 mgper 1 Tablet(s)DSLD:27580
- Nutri-WestStress/PAN-FThiamine Pyrophosphate Note: coenzyme2 mgper 1 Tablet(s)DSLD:28269
- Nutri-WestTotal Alpha Lipoic Acid2 mgper 1 Tablet(s)DSLD:28291
Label record: NIH Office of Dietary Supplements · CC0
Other names
11 names
Resolves to: thiamine(1+) diphosphate
- Also called
- 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-iumThDPthiamin diphosphatethiamin pyrophosphatethiamine diphosphatethiamine pyrophosphatethiamine-pyrophosphateThPPTPP
- Systematic name
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(diphosphooxy)ethyl]-4-methyl-1,3-thiazol-3-ium