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(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

10 compounds within 3 steps: 1 in 1, 2 in 2, 7 in 3

Does it reach a compound?

One step

15(S)-HPETEReach from here →
1. palmitoyl-CoA hydrolase (15(S)-HPETE)
No catalyst recordedcytosol

Two steps

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. palmitoyl-CoA hydrolase (15(S)-HPETE)
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol
glutathione disulfideReach from here →
1. palmitoyl-CoA hydrolase (15(S)-HPETE)
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

Three steps

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
L-cystineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 more

cytosol

CHEBI:16856Reach from here →

palmitoyl-CoA hydrolase (15(S)-HPETE)
Glutathione: 15-HPETE oxidoreductase
Glutathione: 15-HPETE oxidoreductase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 8 routes

methylarsonateReach from here →

palmitoyl-CoA hydrolase (15(S)-HPETE)
Glutathione: 15-HPETE oxidoreductase
methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

thiosulfateReach from here →

palmitoyl-CoA hydrolase (15(S)-HPETE)
Glutathione: 15-HPETE oxidoreductase
thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →

palmitoyl-CoA hydrolase (15(S)-HPETE)
Glutathione: 15-HPETE oxidoreductase
(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 3 routes

glutathioneReach from here →

palmitoyl-CoA hydrolase (15(S)-HPETE)
Glutathione: 15-HPETE oxidoreductase
2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 4 routes