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Proteins/UNIPROT:P10515
The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); (Probable). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation (Probable)..
Function from UniProtKB (P10515), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
102 statements
102 statements · 7 reference databases · Subject: DLAT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, UniProt, WikiPathways
3 reactions
CHEBI:1146900+MAM02869mCHEBI:15351+MAM01701m
Reaction pageLeft to rightBalancedEC 2.3.1.12mitochondrial matrix
Human-GEM MAR06412CC BY 4.0Reference data
2-(1-hydroxyethyl)thiamine diphosphate+MAM02393mMAM02869m+thiamine(1+) diphosphate
8 names
Resolves to: DLAT
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR20069CC BY 4.0Reference data
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]+acetyl-CoAN(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]+coenzyme A(4-)
Catalysed by DLAT
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:17017CC BY 4.0Reference data