thiamine(1+) diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

35 compounds within 3 steps: 6 in 1, 9 in 2, 20 in 3

One step

CHEBI:16284Reach from here →
1. Antiport of thiamine-diphosphate and dATP
Catalysed by SLC25A19mitochondrial matrix, cytosolOne of 2 routes
2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
1. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
Catalysed by BCKDHA, BCKDHBmitochondrial matrix
3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
1. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)
Catalysed by BCKDHA, BCKDHBmitochondrial matrix
2-methyl-1-hydroxypropylthiamine diphosphateReach from here →
1. branched chain keto acid dehydrogenase E1 (3-methyl-2-oxobutyrate)
Catalysed by BCKDHA, BCKDHBmitochondrial matrix
thiamine triphosphateReach from here →
1. ATP:thiamine-diphosphate phosphotransferase
Catalysed by TPK1cytosol
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by PDHA1, PDHB, PDHA2mitochondrial matrix

Two steps

alpha-D-glucosamine 6-phosphateReach from here →
1. Antiport of thiamine-diphosphate and dATP
2. dATP:D-glucosamine 6-phosphotransferase
Catalysed by SLC25A19, HK1, HK2, HKDC1mitochondrial matrix, cytosol
keto-D-fructose 6-phosphateReach from here →
1. Antiport of thiamine-diphosphate and dATP
2. dATP:D-fructose 6-phosphotransferase
Catalysed by SLC25A19, HK1, HK2, HK3 and 1 more

Three steps

CHEBI:1146900Reach from here →
Catalysed by SLC25A19, HK1, HK2, HKDC1 and 1 moremitochondrial matrix, cytosol
pyruvateReach from here →
Catalysed by and 4 more

mitochondrial matrix, cytosol

CHEBI:16174Reach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 2 moremitochondrial matrix, cytosolOne of 20 routes

dTDPReach from here →

Catalysed by SLC25A19, DTYMKmitochondrial matrix, cytosolOne of 2 routes

dTTPReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 3 moremitochondrial matrix, cytosolOne of 3 routes

CHEBI:28862Reach from here →

Catalysed by SLC25A19mitochondrial matrix, cytosol

D-glucopyranose 6-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 1 moremitochondrial matrix, cytosol

dCDPReach from here →

Catalysed by SLC25A19, CMPK1mitochondrial matrix, cytosolOne of 2 routes

thiamine diphosphateReach from here →

Catalysed by TPK1, THTPAcytosolOne of 2 routes

SLC25A19

, NME4

, NME6

, NME1

mitochondrial matrix, cytosol

One of 3 routes

thioredoxin dithiolReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 7 moremitochondrial matrix, cytosolOne of 4 routes

CHEBI:16332Reach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 4 moremitochondrial matrix, cytosol

CHEBI:16497Reach from here →

Catalysed by SLC25A19, CMPK1mitochondrial matrix, cytosolOne of 11 routes

D-erythrose 4-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 4 moremitochondrial matrix, cytosol

thymidineReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 4 moremitochondrial matrix, cytosol

triphosphateReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 4 moremitochondrial matrix, cytosol

CHEBI:29052Reach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 2 moremitochondrial matrix, cytosol

D-glucoseReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 4 moremitochondrial matrix, cytosol, endoplasmic reticulum

phosphoenolpyruvic acidReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 5 moremitochondrial matrix, cytosol

D-sedoheptulose 7-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 2 moremitochondrial matrix, cytosol

N-acetyl-D-glucosamine 6-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HKDC1 and 1 moremitochondrial matrix, cytosol

dCMPReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 3 moremitochondrial matrix, cytosolOne of 20 routes

beta-D-fructose 6-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HKDC1 and 2 moremitochondrial matrix, cytosol

dGMPReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 2 moremitochondrial matrix, cytosolOne of 3 routes

6-phospho-D-glucono-1,5-lactoneReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 2 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

1D-myo-inositol 3-phosphateReach from here →

Catalysed by SLC25A19, HK1, HK2, HK3 and 2 moremitochondrial matrix, cytosol

dCTPReach from here →

Catalysed by SLC25A19, CMPK1, NME4, NME6 and 4 moremitochondrial matrix, cytosolOne of 11 routes

dTMPReach from here →

Catalysed by SLC25A19, NME4, NME6, NME1 and 3 moremitochondrial matrix, cytosolOne of 8 routes