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Proteins/UNIPROT:Q9NZV6
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages..
Function from UniProtKB (Q9NZV6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
97 statements
97 statements · 7 reference databases · Subject: MSRB1 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
2 reactions
[thioredoxin]-disulfide+L-methionine+waterL-methionine (R)-S-oxide+[thioredoxin]-dithiol
Catalysed by MSRB3 or MSRB1 or MSRB2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21260CC BY 4.0Reference data
L-methionyl-[protein]+[thioredoxin]-disulfide+waterL-methionyl-(R)-S-oxide-[protein]+[thioredoxin]-dithiol
Catalysed by MSRB3
3 names
Resolves to: MSRB1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24164CC BY 4.0Reference data