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Proteins/UNIPROT:Q9NZB8
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP..
[Isoform 9]: Has very weak catalytic activity..
Function from UniProtKB (Q9NZB8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
11 statements
11 statements · 4 reference databases · Subject: MOCS1 · Sources: Hetionet, Rhea, UniProt, WikiPathways
3 reactions
GTP+waterMAM01618c+diphosphate(3-)
Catalysed by MOCS1
Reaction pageLeft to rightBalancedEC 4.1.99.22, 4.6.1.17cytosol
Human-GEM MAR07145CC BY 4.0Reference data
GTP+AH2+S-adenosyl-L-methionine(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate+5'-deoxyadenosine+L-methionine+A
7 names
Resolves to: MOCS1
Catalysed by MOCS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:49576CC BY 4.0Reference data
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphatecyclic pyranopterin phosphate+diphosphate(3-)
Catalysed by MOCS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:49580CC BY 4.0Reference data