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Proteins/UNIPROT:P11177
Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (Probable). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2..
Function from UniProtKB (P11177), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
223 statements
223 statements · 8 reference databases · Subject: PDHB · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
proton+pyruvate+thiamine(1+) diphosphate2-(1-hydroxyethyl)thiamine diphosphate+carbon dioxide
Catalysed by PDHA1 & PDHB or PDHB & PDHA2
Reaction pageLeft to rightBalancedEC 1.2.4.1mitochondrial matrix
Human-GEM MAR08746CC BY 4.0Reference data
2-(1-hydroxyethyl)thiamine diphosphate+MAM02393mMAM02869m+thiamine(1+) diphosphate
2 names
Resolves to: PDHB
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR20069CC BY 4.0Reference data
N(6)-[(R)-lipoyl]-L-lysyl-[protein]+pyruvate+hydronN(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]+carbon dioxide
Catalysed by PDHA1 or PDHB or PDHA2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19189CC BY 4.0Reference data