cholesterol sulfate

Three steps

• a quinoneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by STS, SLC25A10, SDHBcytosol, mitochondrial matrix

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by STS, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (24S)-hydroxycholesterol 24-sulfateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by STS, CYP46A1, SULT2A1cytosol, endoplasmic reticulum

• (24S)-hydroxycholesterol 3-sulfateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by STS, CYP46A1, SULT2B1, SULT1E1 and 1 morecytosol, endoplasmic reticulum

• indoxyl sulfateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (7Z)-octadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 3 routes

• CHEBI:15345Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, AACScytosol, endoplasmic reticulumOne of 2 routes

• cholineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by STS, SOAT2, SOAT1, CHATcytosol, endoplasmic reticulum, nucleusOne of 2 routes

• pyruvateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate:NAD+ oxidoreductase (decarboxylating)

  Catalysed by STS, SLC25A10, ME2, ME3cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:15380Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by STS, SOAT2, SOAT1, ALAS1 and 1 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by STS, SOAT2, SOAT1, GLYAT and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 1 morecytosol, endoplasmic reticulumOne of 2 routes

• isobutyryl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by STS, SOAT2, SOAT1, GLYATcytosol, endoplasmic reticulum, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by STS, SOAT2, SOAT1, GLYAT and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 11 routes

• CHEBI:15519Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by STS, SOAT2, SOAT1, ACAA1 and 2 morecytosol, endoplasmic reticulum, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 11 routes

• oleoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 3 routes

• propionyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, ACSS3 and 2 morecytosol, endoplasmic reticulumOne of 43 routes

• L-leucineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• CHEBI:15650Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by STS, SOAT2, SOAT1, ZDHHC11B and 31 morecytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15727Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by STS, SOAT2, SOAT1, NAA10cytosol, endoplasmic reticulum

• formateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by STS, SLC25A14, SLC26A2, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15746Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by STS, SOAT2, SOAT1, SAT1 and 1 morecytosol, endoplasmic reticulumOne of 2 routes

• hexadecanoic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by STS, SLC22A6, QPRTcytosol, extracellular space

• N-carbamoyl-L-aspartic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• CHEBI:15971Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• androsteroneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by STScytosolOne of 3 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by STS, LCAT, LPCAT4, LPCAT3 and 2 morecytosol

• cholesterolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by STS, LCAT, CES1, LIPN and 2 morecytosolOne of 3 routes

• L-cystineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by STS, SOAT2, SOAT1, DGAT1 and 4 morecytosol, endoplasmic reticulum

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by STScytosolOne of 3 routes

• iodideReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular space

• ubiquinonesReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by STS, SLC25A10, SDHD, SDHB and 2 morecytosol, mitochondrial matrix

• L-valineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by STS, SOAT2, SOAT1, ACLYcytosol, endoplasmic reticulumOne of 12 routes

• L-arginineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by STS, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membrane

• 3-fumarylpyruvateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by STS, SLC25A10, FAHD1cytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• sn-glycerol 3-phosphocholineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by STS, LCAT, LYPLA1, LYPLA2 and 8 morecytosol

• ferrocytochrome cReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by STS, SLC25A14, SLC25A30, SUOXcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• progesteroneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cytochrome P450 (cholesterol)
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by STS, CYP11A1, HSD3B1, HSD3B2cytosol, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular spaceOne of 3 routes