progesterone

1. progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4, CYP1B1

1. cytochrome P450 (progesterone)

Catalysed by CYP21A2cytosolOne of 3 routes

1. cytochrome P450 (progesterone)

Catalysed by CYP17A1cytosolOne of 3 routes

1. progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

Catalysed by CYP11B1, CYP11B2cytosolOne of 2 routes

1. (20S)-hydroxypregn-4-en-3-one + NAD(+) = progesterone + NADH + H(+)

Catalysed by AKR1C4, HSD17B2, AKR1C3, AKR1C2 and 1 moreOne of 2 routes

1. 5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

Catalysed by SRD5A1, SRD5A2, SRD5A3cytosolOne of 2 routes

1. progesterone + NADPH + H(+) = 5beta-pregnan-3,20-dione + NADP(+)

Catalysed by AKR1D1

1. 20alpha-Hydroxy-4-pregnen-3-one:NADP+ 20-oxidoreductase

Catalysed by AKR1C1cytosol

1. progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4, CYP3A5, CYP1B1

1. progesterone + NADPH + H(+) = 3beta-hydroxypregn-4-ene-20-one + NADP(+)

Catalysed by HSD17B7

1. cytochrome P450 (progesterone)
2. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by CYP17A1cytosol, endoplasmic reticulum

1. cytochrome P450 (progesterone)
2. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

Catalysed by CYP17A1, AKR1C1cytosolOne of 2 routes

1. cytochrome P450 (progesterone)
2. cytochrome P450 (17alpha-hydroxyprogesterone)
3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

Catalysed by CYP17A1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

1. cytochrome P450 (progesterone)
2. cytochrome P450 (17alpha-hydroxyprogesterone)
3. N-acetylcadaverine + H2O = cadaverine + acetate