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Proteins/UNIPROT:P49888
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system..
Function from UniProtKB (P49888), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 7 reference databases · Subject: SULT1E1 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
3beta-hydroxyandrost-5-en-17-one+3'-phospho-5'-adenylyl sulfatedehydroepiandrosterone 3-sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1E1
Reaction pageLeft to rightBalancedEC 2.8.2.4cytosol
Human-GEM MAR01969CC BY 4.0Reference data
estrone+3'-phospho-5'-adenylyl sulfateestrone 3-sulfate+proton+adenosine 3',5'-bismonophosphate
5 names
Resolves to: SULT1E1
Reaction pageLeft to rightBalancedEC 2.8.2.4cytosol
Human-GEM MAR02037CC BY 4.0Reference data
estrone+3'-phosphoadenylyl sulfateestrone 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1E1
Reaction pageLeft to rightBalanced
Rhea RHEA:15973CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+3'-phosphoadenylyl sulfatedehydroepiandrosterone 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1E1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:51216CC BY 4.0Reference data
(24S)-hydroxycholesterol+3'-phosphoadenylyl sulfate(24S)-hydroxycholesterol 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1E1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52348CC BY 4.0Reference data
17beta-estradiol+3'-phosphoadenylyl sulfate17beta-estradiol 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C4 or SULT1E1 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52372CC BY 4.0Reference data
4-ethylphenol+3'-phosphoadenylyl sulfate4-ethylphenyl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1E1 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:70607CC BY 4.0Reference data