Compound

cholesterol sulfate

A steroid sulfate oxoanion obtained by deprotonation of the sulfo group of cholesterol sulfate; major species at pH 7.3.

Definition from ChEBI (CHEBI:136579), read 2026-09-23. CC BY 4.0.

CHEBI:136579ChEBI

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Structure

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A generated conformer of cholesterol sulfate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C27H45O4S
Mass: 465.72 g/mol
Charge: -1
InChIKey: BHYOQNUELFTYRT-DPAQBDIFSA-M
SMILES: [H][C@@]12CC=C3C[C@@H](OS(=O)(=O)[O-])CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@H](C)CCCC(C)C
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

STSProteinUNIPROT:P08842substrate ofInferred only56 paths14 endpoints

What the reference databases state

Statements

6 statements

6 statements · 2 reference databases · Subject: cholesterol sulfate · Sources: Human-GEM, Rhea

Order

CHEBI:1307929 is converted to cholesterol sulfateCompoundHuman-GEM MAR01919Inferred only
cholesterol is converted to cholesterol sulfateCompoundRhea RHEA:52368Inferred only
cholesterol sulfate is a substrate of STSProteinHuman-GEM MAR01920Inferred only
cholesterol sulfate is a substrate of STSProteinHuman-GEM MAR02747Inferred only
cholesterol sulfate is a substrate of STSProteinHuman-GEM MAR02749Inferred only
cholesterol sulfate is a substrate of STSProteinHuman-GEM MAR07950Inferred only

Reactions

10 reactions

CHEBI:1307929+3'-phospho-5'-adenylyl sulfatecholesterol sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT2B1 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.2cytosol
Human-GEM MAR01919CC BY 4.0Reference data
cholesterol sulfate+waterCHEBI:1307929+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol
Human-GEM MAR01920CC BY 4.0Reference data
cholesterol sulfate+waterCHEBI:1307929+proton+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2Golgi apparatus
Human-GEM MAR02747CC BY 4.0Reference data
cholesterol sulfate+waterCHEBI:1307929+proton+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2lysosome
Human-GEM MAR02749CC BY 4.0Reference data
cholesterol sulfatecholesterol sulfate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07949CC BY 4.0Reference data
cholesterol sulfate+waterCHEBI:1307929+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR07950CC BY 4.0Reference data
cholesterol sulfatecholesterol sulfate
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11888CC BY 4.0Reference data
cholesterol sulfate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11889CC BY 4.0Reference data
cholesterol+3'-phosphoadenylyl sulfatecholesterol sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1C2
Reaction pageLeft to rightBalanced
Rhea RHEA:52368CC BY 4.0Reference data
cholesterol sulfate+reduced [NADPH--hemoprotein reductase]+dioxygen(24S)-hydroxycholesterol 3-sulfate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:58840CC BY 4.0Reference data

Other names

4 names

Resolves to: cholesterol sulfate

Also called: (3beta)-cholest-5-en-3-yl sulfate(3β)-cholest-5-en-3-yl sulfate
Systematic name: cholest-5-en-3beta-yl sulfatecholest-5-en-3β-yl sulfate