Compound
progesterone
No description recorded for this entry yet. Everything this graph holds about progesterone is below.
Structure
- Class
- Organic compound
- Formula
- C21H30O2
- Mass
- 314.469 g/mol
- Charge
- 0
- InChIKey
- RJKFOVLPORLFTN-LEKSSAKUSA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What it touches on the way
A finding says progesterone moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
19 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
19 entities
19 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hops19 assembled from the scaffold
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only96 paths48 endpoints
- CYP17A1ProteinUNIPROT:P05093metabolized byInferred only66 paths22 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only62 paths31 endpoints
- CYP1B1ProteinUNIPROT:Q16678metabolized byInferred only58 paths29 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only46 paths23 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only42 paths21 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only32 paths16 endpoints
- CYP11B2ProteinUNIPROT:P19099metabolized byInferred only23 paths23 endpoints
- CYP21A2ProteinUNIPROT:P08686metabolized byInferred only21 paths21 endpoints
- HSD3B1ProteinUNIPROT:P14060substrate ofInferred only18 paths18 endpoints
- HSD3B2ProteinUNIPROT:P26439substrate ofInferred only18 paths18 endpoints
- CYP46A1ProteinUNIPROT:Q9Y6A2metabolized byInferred only16 paths16 endpoints
Show the remaining 7
- CYP3A5ProteinUNIPROT:P20815metabolized byInferred only15 paths15 endpoints
- AKR1D1ProteinUNIPROT:P51857substrate ofInferred only15 paths15 endpoints
- GSTA3ProteinUNIPROT:Q16772metabolized byInferred only14 paths14 endpoints
- SRD5A2ProteinUNIPROT:P31213substrate ofInferred only13 paths13 endpoints
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only13 paths13 endpoints
- HSD17B2ProteinUNIPROT:P37059substrate ofInferred only12 paths12 endpoints
- SRD5A1ProteinUNIPROT:P18405substrate ofInferred only11 paths11 endpoints
What the reference databases state
The section above shows paths a projection assembled. This is the reference layer itself, one step from progesterone: what the cleared databases state it reacts with, is carried by, is converted to and takes part in, whether or not a projection has walked it yet.
Regulatory determinations
Published numbers and scores, transcribed from the body that issued them. A determination is not a finding and is not graded; it is the number, who set it, and the document it came from.
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Progestins". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
39 statements
39 statements in 2 reference databases name progesterone — Human-GEM, Rhea. Press a relation to see only its rows; every count is the rows behind it.
- (20S)-hydroxypregn-4-en-3-one is converted to progesteroneCompoundRhea RHEA:42108Inferred only
- (20S)-hydroxypregn-4-en-3-one is converted to progesteroneCompoundRhea RHEA:42112Inferred only
- progesterone is converted to (20S)-hydroxypregn-4-en-3-oneCompoundRhea RHEA:42108Inferred only
- progesterone is converted to (20S)-hydroxypregn-4-en-3-oneCompoundRhea RHEA:42112Inferred only
- 3beta-hydroxypregn-4-ene-20-one is converted to progesteroneCompoundRhea RHEA:46216Inferred only
- progesterone is converted to 3beta-hydroxypregn-4-ene-20-oneCompoundRhea RHEA:46216Inferred only
- 5alpha-pregnane-3,20-dione is converted to progesteroneCompoundRhea RHEA:21952Inferred only
- progesterone is converted to 5alpha-pregnane-3,20-dioneCompoundRhea RHEA:21952Inferred only
- progesterone is converted to 5beta-pregnan-3,20-dioneCompoundRhea RHEA:46660Inferred only
- 5beta-pregnan-3,20-dione is converted to progesteroneCompoundRhea RHEA:46660Inferred only
- pregn-5-ene-3,20-dione is converted to progesteroneCompoundRhea RHEA:43928Inferred only
- progesterone is converted to pregn-5-ene-3,20-dioneCompoundRhea RHEA:43928Inferred only
Show the remaining 27
- progesterone is metabolised by CYP11B2ProteinRhea RHEA:84067Inferred only
- progesterone is metabolised by CYP17A1ProteinRhea RHEA:46308Inferred only
- progesterone is metabolised by CYP17A1ProteinHuman-GEM MAR07937Inferred only
- progesterone is metabolised by CYP17A1ProteinHuman-GEM MAR01981Inferred only
- progesterone is metabolised by CYP1B1ProteinRhea RHEA:47260Inferred only
- progesterone is metabolised by CYP1B1ProteinRhea RHEA:47252Inferred only
- progesterone is metabolised by CYP21A2ProteinRhea RHEA:50304Inferred only
- progesterone is metabolised by CYP3A4ProteinRhea RHEA:47260Inferred only
- progesterone is metabolised by CYP3A4ProteinRhea RHEA:47252Inferred only
- progesterone is metabolised by CYP3A5ProteinRhea RHEA:47252Inferred only
- progesterone is metabolised by CYP46A1ProteinRhea RHEA:46308Inferred only
- progesterone is metabolised by GSTA3ProteinRhea RHEA:43928Inferred only
- progesterone is a substrate of AKR1C1ProteinRhea RHEA:42108Inferred only
- progesterone is a substrate of AKR1C1ProteinRhea RHEA:42112Inferred only
- progesterone is a substrate of AKR1C2ProteinRhea RHEA:42108Inferred only
- progesterone is a substrate of AKR1C2ProteinRhea RHEA:42112Inferred only
- progesterone is a substrate of AKR1C3ProteinRhea RHEA:42108Inferred only
- progesterone is a substrate of AKR1C3ProteinRhea RHEA:42112Inferred only
- progesterone is a substrate of AKR1C4ProteinRhea RHEA:42112Inferred only
- progesterone is a substrate of AKR1C4ProteinRhea RHEA:42108Inferred only
- progesterone is a substrate of AKR1D1ProteinRhea RHEA:46660Inferred only
- progesterone is a substrate of HSD17B2ProteinRhea RHEA:42108Inferred only
- progesterone is a substrate of HSD17B7ProteinRhea RHEA:46216Inferred only
- progesterone is a substrate of HSD3B1ProteinRhea RHEA:43928Inferred only
- progesterone is a substrate of HSD3B2ProteinRhea RHEA:43928Inferred only
- progesterone is a substrate of SRD5A1ProteinRhea RHEA:21952Inferred only
- progesterone is a substrate of SRD5A2ProteinRhea RHEA:21952Inferred only
Other names
17 names
Every name this graph resolves to progesterone. Searching any of them lands here.
- Also called
- (S)-4-Pregnene-3,20-dione(S)-Pregn-4-en-3,20-dione(S)-Progesterone17alpha-progesterone17α-progesterone4-Pregnene-3,20-dioneAgolutinAkrolutincorpus luteum hormoneCrinoneDelta(4)-pregnene-3,20-dioneGelbkoerperhormonluteohormoneProgesteronST 21:3;O2Δ4-pregnene-3,20-dione
- Systematic name
- pregn-4-ene-3,20-dione