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Proteins/UNIPROT:O00204
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation..
[Isoform 2]: Sulfonates pregnenolone but not cholesterol..
Function from UniProtKB (O00204), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
117 statements
117 statements · 7 reference databases · Subject: SULT2B1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Rhea, WikiPathways
8 reactions
CHEBI:1307929+3'-phospho-5'-adenylyl sulfatecholesterol sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT2B1 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.2cytosol
Human-GEM MAR01919CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+pregnenoloneproton+adenosine 3',5'-bismonophosphate+
6 names
Resolves to: SULT2B1
Catalysed by SULT2B1
Reaction pageLeft to rightBalancedEC 2.8.2.2cytosol
Human-GEM MAR01952CC BY 4.0Reference data
17alpha-hydroxypregnenolone+3'-phospho-5'-adenylyl sulfateMAM00407c+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT2B1
Reaction pageLeft to rightBalancedEC 2.8.2.2cytosol
Human-GEM MAR01962CC BY 4.0Reference data
an alcohol+3'-phosphoadenylyl sulfatean alkyl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT2A1 or SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22552CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+3'-phosphoadenylyl sulfatedehydroepiandrosterone 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1E1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:51216CC BY 4.0Reference data
(24S)-hydroxycholesterol+3'-phosphoadenylyl sulfate(24S)-hydroxycholesterol 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1E1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52348CC BY 4.0Reference data
pregnenolone+3'-phosphoadenylyl sulfatepregnenolone sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52356CC BY 4.0Reference data
cholesterol+3'-phosphoadenylyl sulfatecholesterol sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2B1 or SULT1C2
Reaction pageLeft to rightBalanced
Rhea RHEA:52368CC BY 4.0Reference data