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Proteins/UNIPROT:O95372
Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity. Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide..
Function from UniProtKB (O95372), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
100 statements
100 statements · 5 reference databases · Subject: LYPLA2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
8 reactions
1-O-acyl-sn-glycero-3-phosphocholine(1+)+waterproton+sn-glycerol 3-phosphocholine+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
6 names
Resolves to: LYPLA2
MAM00511c+waterproton+MAM02913c+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
Human-GEM MAR00645CC BY 4.0Reference data
S-hexadecanoyl-L-cysteinyl-[protein]+waterL-cysteinyl-[protein]+hexadecanoate+hydron
Catalysed by CLN5 or LYPLA1 or LYPLA2 or PPT1 or ABHD17B or LYPLAL1 or DESI1 or ABHD17C or CPT1C or ABHD17A or DESI2 or ABHD10
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19233CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40435CC BY 4.0Reference data
1-octadecanoyl-sn-glycero-3-phosphocholine+wateroctadecanoate+sn-glycerol 3-phosphocholine+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40887CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phospho-L-serine+watersn-glycero-3-phospho-L-serine+hexadecanoate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:44552CC BY 4.0Reference data
prostaglandin E2 1-glyceryl ester+waterprostaglandin E2+glycerol+hydron
Catalysed by CES2 or LYPLA2 or CES1 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:48296CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphate+watersn-glycerol 3-phosphate+hexadecanoate+hydron
Catalysed by LYPLA2 or PNPLA7 or PNPLA6
Reaction pageLeft to rightBalanced
Rhea RHEA:49092CC BY 4.0Reference data