Se-methylselenocysteine

Three steps

• (S)-lactoyl-AMPReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by SCLY, LDHA, LDHB, LDHC and 4 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by SCLY, PKM, PKLR, NANScytosol

• CHEBI:240943Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SHMT1, GLYAT, GLYATL2, GLYATL1nucleus, cytosol, mitochondrial matrix

• a quinolReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SCLY, ME2, SDHB, SDHAcytosol

• folic acidReach from here →
  1. Methionine Synthase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by DHFR, DHFR2nucleus, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SHMT1, GLYATnucleus, cytosolOne of 3 routes

• 3-mercaptolactic acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by SCLY, MPST, LDHB, LDHC and 2 morecytosol

• 2-oxopentanoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by SCLY, AGXT2cytosol

• CHEBI:28666Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. LTD4 hydrolysis

  Catalysed by SHMT1nucleus, cytosol

• 17alpha-hydroxypregnenoloneReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYcytosolOne of 3 routes

• N-glycoloylneuraminateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by SCLY, NPLcytosol

• a carboxylateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SCLY, FAHD1cytosol

• Gly-tRNA(Gly)Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SHMT1, GARS1nucleus, cytosol

• chlorine(.)Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC6A9, SLC6A14nucleus, cytosol, extracellular spaceOne of 9 routes

• glycocholateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SHMT1, BAATnucleus, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by SCLY, MPSTcytosol

• L-aspartateReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by SCLY, AGXT2cytosolOne of 8 routes

• citric acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by SCLY, PC, CScytosol, mitochondrial matrixOne of 9 routes

• isocitric acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. transport of isocitrate and PEP (cytosol to mitochondria)

  Catalysed by SCLY, PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SCLY, PC, GOT2cytosol, mitochondrial matrix

• cis-aconitic acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. transport of cis-aconitate and PEP (cytosol to mitochondria)

  Catalysed by SCLY, PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• thiosulfateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and thiosulfate (cytosol to mitochondria)

  Catalysed by SCLY, ME2, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SCLY, TYW1B, TYW1, IL4I1cytosol

• 2-oxohexanoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by SCLY, AGXT2cytosol

• D-cysteineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by CTH, GPTnucleus, cytosol

• 5-aminolevulinateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SHMT1, ALAS1, ALAS2nucleus, cytosol

• glycochenodeoxycholateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SHMT1, BAATnucleus, cytosol

• glycochenodeoxycholic acidReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SHMT1, BAATnucleus, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by CTH, AGXT2nucleus, cytosolOne of 19 routes

• glycolithocholic acidReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SHMT1, BAATnucleus, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SHMT1, GCATnucleus, cytosol, mitochondrial matrix

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by SCLY, HMGCL, HMGCLL1cytosol, mitochondrial matrix

• 13-cis-retinalReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space, endoplasmic reticulum

• L-ornithineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SHMT1, GATMnucleus, cytosolOne of 12 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SCLY, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SHMT1, GLDC, GCSHnucleus, cytosol, mitochondrial matrix

• acetoacetyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by SCLY, AACScytosol, mitochondrial matrixOne of 2 routes

• (S)-malyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SCLY, ME2, SUCLG1, SUCLA2cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SCLY, AGXT2, ALDH6A1cytosol, mitochondrial matrix

• butanoyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 9 morecytosol, extracellular spaceOne of 2 routes

• propanoyl-CoAReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
  3. 2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)

  Catalysed by SCLY, AGXT2, ALDH6A1cytosol

• prostaglandin E1Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin D2Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-alanineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes