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Proteins/UNIPROT:Q8TB92
Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues..
Function from UniProtKB (Q8TB92), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 6 reference databases · Subject: HMGCLL1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
CHEBI:15467acetoacetate+CHEBI:15351
Reaction pageLeft to rightBalancedEC 4.1.3.4mitochondrial matrix
Human-GEM MAR01577CC BY 4.0Reference data
(3S)-3-hydroxy-3-methylglutaryl-CoAacetoacetate+acetyl-CoA
Reaction pageDirection not assertedBalanced
4 names
Resolves to: HMGCLL1