(3S)-3-hydroxy-3-methylglutaryl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

208 compounds within 3 steps: 5 in 1, 23 in 2, 180 in 3

Two steps

(S)-3-hydroxybutanoateReach from here →
1. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
2. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate
Catalysed by HMGCL, HMGCLL1, ADHFE1
CHEBI:1146900Reach from here →
1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
2. Production of Glutaryl Carnitine
Catalysed by SUGCT, CPT1A, CPT1C, CPT1Bcytosol

Three steps

2-hydroxybutyric acid

Reach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 2 moreextracellular space, cytosolOne of 2 routes

CHEBI:15345Reach from here →

Catalysed by HMGCL, HMGCLL1, AACScytosolOne of 3 routes

acetoneReach from here →

Catalysed by HMGCL, HMGCLL1mitochondrial matrix

pyruvateReach from here →

Catalysed by HMGCL, HMGCLL1mitochondrial matrix, cytosolOne of 4 routes

all-trans-retinoic acidReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

(R)-3-hydroxybutyric acidReach from here →

Catalysed by HMGCL, HMGCLL1, BDH1, BDH2mitochondrial matrixOne of 4 routes

succinyl-4'-phosphopantetheineReach from here →

Catalysed by SUGCT, NUDT19, NUDT7, NUDT8

4-fumarylacetoacetateReach from here →

Catalysed by HMGCL, HMGCLL1, FAH

acetateReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

formic acidReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

propionic acidReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

butyric acidReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

glutarateReach from here →

Catalysed by SUGCTOne of 6 routes

5-aminolevulinateReach from here →

Catalysed by SUGCT, ALAS1, ALAS2

(S)-lactic acidReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

acetoacetyl-CoAReach from here →

Catalysed by SUGCT, OXCT1One of 3 routes

(2E)-butenoyl-CoAReach from here →

Catalysed by SUGCT, GCDHmitochondrial matrixOne of 2 routes

(2E)-glutaconyl-CoAReach from here →

Catalysed by SUGCT, ACOX1

itaconyl-CoAReach from here →

Catalysed by SUGCTOne of 2 routes

hexanedioyl-CoAReach from here →

Catalysed by SUGCT

a 3-oxoacyl-CoAReach from here →

Catalysed by SUGCT, OXCT1, OXCT2

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 more

extracellular space, cytosol

One of 2 routes

prostaglandin A2Reach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosolOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 1 moreextracellular space, cytosolOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 3 moreextracellular space, cytosol, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 25 moreextracellular space, cytosolOne of 2 routes

a phenyl acetateReach from here →

Catalysed by HMGCL, HMGCLL1, SLC16A4, SLC16A5 and 6 moreextracellular space, cytosol

(7Z)-octadecenoyl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

cholineReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 1 morecytosol, nucleus

acetylpyruvateReach from here →

Catalysed by HMGCL, HMGCLL1, FAHD1mitochondrial matrix, cytosolOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 2 morecytosol, mitochondrial matrixOne of 9 routes

CHEBI:15467Reach from here →

Catalysed by HMGCL, HMGCLL1, AACS, HMGCS1cytosolOne of 3 routes

CHEBI:15477Reach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 3 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 3 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 1 morecytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 3 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 8 morecytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 3 morecytosol, peroxisomeOne of 2 routes

(3S)-3-hydroxy-3-methylglutaryl-CoA

One step

Two steps

Three steps