Reaction
(3S)-3-hydroxy-3-methylglutaryl-CoAacetoacetate+acetyl-CoA
Direction not asserted · Balanced
Kinetics
Km 0.18 µM · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA (in presence of manganese)”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22865860
Km 28 µM · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22865860
Km 40 µM · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA (at pH 9)”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22847177
Km 49 µM · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA (in presence of magnesium)”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22865860
Km 75 µM · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA (at pH 8)”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22847177
Vmax 12 nmol/min/mg · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22847177
Vmax 25 nmol/min/mg · (3S)-3-hydroxy-3-methylglutaryl-CoA · HMGCLL1
Measured · human enzyme; other conditions not stated · as “(S)-3-hydroxy-3-methylglutaryl-CoA”
UniProt Q8TB92 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 22847177
Rhea RHEA:24404·2026-08-19·CC BY 4.0Reference data