L-tyrosine

Three steps

• cholateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by AADAT, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• glycolateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by TAT, AADAT, GRHPROne of 3 routes

• hydrogen sulfideReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by PAH, SLC7A5, CTHextracellular space, cytosolOne of 3 routes

• D-aspartateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A13, SLC1A7, SLC1A3, SLC1A2 and 2 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-Acetyl-L-aspartate amidohydrolase

  Catalysed by SLC7A13, NAT8L, ASPA, ACY3inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by TH, TPH1, TPH2, IDO1 and 2 morecytosol

• oxalateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by TAT, AADAT, HAO1One of 3 routes

• formic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PAH, SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by PAH, SLC7A8, KYNUextracellular space, cytosol

• citric acidReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by SLC7A13, GOT2, CSinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• maleateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Malonate Transport, Antiport with Chloride

  Catalysed by PAH, SLC6A14extracellular space, cytosolOne of 4 routes

• (9Z)-octadecenoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by PAH, PM20D1One of 2 routes

• (indol-3-yl)acetateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• an alcoholReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by AADAT, GSS, CP, PRDX6

• glutarateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by AADAT, BAAT, SLC22A24peroxisome, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC7A13, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by PAH, PM20D1One of 4 routes

• L-lysineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by PAH, SLC7A5, SLC7A7extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-lysineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by PAH, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by PAH, SLC7A6, SLC3A2, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by PAH, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC7A13, GAD2, AGXT2inner side of the membrane, outer side of the membrane, cytosol

• thiosulfateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC7A13, SLC25A14, SLC25A30, SLC26A1 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by PAH, SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by PAH, SLC7A5, NDUFAB1, FDXR and 5 moreextracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by PAH, TPH1, TPH2, DDCOne of 5 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by PAH, SLC7A5, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by PAH, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by PAH, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 3-methyl-2-oxovaleric acidReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by PAH, SLC7A5, BCAT1extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by AADAT, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• CHEBI:37946Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. L-dopa + H(+) = dopamine + CO2
  3. aryl sulfotransferase (dopamine)

  Catalysed by TH, DDC, SULT1A3, SULT1A4 and 2 morecytosol

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• phosphoenolpyruvic acidReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by SLC7A13, GOT2, PCK1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• tert-butanolReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by AADAT, GSS, CLIC2, GPX1 and 3 more

• 4-maleylacetoacetic acidReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
  3. Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)

  Catalysed by TAT, HPD, HGDcytosol

• gamma-Glu-AlaReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PAH, SLC7A5, GGT1, GGT5 and 4 moreextracellular space, cytosolOne of 2 routes

• taurineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by PAH, SLC6A14, SLC6A6extracellular space, cytosolOne of 4 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by AADAT, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (R)-methylmalonyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AADAT, BAAT, ALDH6A1peroxisome, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by AADAT, BAATperoxisome, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by AADAT, BAAT, ACP2peroxisome, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by AADAT, BAATperoxisome, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AADAT, BAAT, ACAA1, MYO5BperoxisomeOne of 2 routes