Loading the page.
Proteins/UNIPROT:Q96HD9
Deacetylates N-acetyl aromatic amino acids and mercapturic acids (N-acetyl-L-cysteine-S-conjugates), including halogenated mercapturic acids derived from the metabolism of environmental contaminants such as trichloroethylene, making it a key enzyme in the processing of both endogenous and xenobiotic compounds. In neurons and blood vessels, deacetylates the mercapturates of 4-hydroxy-2-nonenal (4HNE) and acrolein (ACR), two highly reactive lipid peroxidation products; the resulting deacetylated products can then be transformed into toxic compounds by beta-lyase..
Function from UniProtKB (Q96HD9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 6 reference databases · Subject: ACY3 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
7 reactions
2water+MAM02866cL-glutamate(1-)+glycine+MAM02867c
Catalysed by SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or SIRT3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05336CC BY 4.0Reference data
9 names
Resolves to: ACY3
water+MAM02548cacetate+MAM02867c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or NAAA or SIRT3 or NTAN1 or MACROD2 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05339CC BY 4.0Reference data
water+MAM02867cammonium+MAM02865c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageLeft to rightBalancedEC 3.5.1.-cytosol
Human-GEM MAR05340CC BY 4.0Reference data
water+MAM02531cacetate+L-asparagine
Reaction pageReversibleBalancedEC 3.5.1.15cytosol
Human-GEM MAR06969CC BY 4.0Reference data
water+N-acetyl-L-aspartateacetate+L-aspartate
Reaction pageLeft to rightBalancedEC 3.5.1.15cytosol
Human-GEM MAR08628CC BY 4.0Reference data
an N-acetyl-L-cysteine-S-conjugate+wateran S-substituted L-cysteine+acetate
Catalysed by ACY3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:36855CC BY 4.0Reference data
an N-acyl-aromatic L-alpha-amino acid+wateran aromatic L-alpha-amino acid+a carboxylate
Reaction pageReversibleBalance undeterminable
Rhea RHEA:54184CC BY 4.0Reference data