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Proteins/UNIPROT:P0DMN0
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4..
Function from UniProtKB (P0DMN0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 6 reference databases · Subject: SULT1A4 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
3'-phospho-5'-adenylyl sulfate+4-nitrophenol4-nitrophenyl sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1A1 or SULT1A2 or SULT1A4 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.1cytosol
Human-GEM MAR07688CC BY 4.0Reference data
3 names
Resolves to: SULT1A4
Reaction pageLeft to rightBalancedEC 2.8.2.1cytosol
Human-GEM MAR07689CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+3,3',5-triiodo-L-thyronine3,3',5-triiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1A1 or SULT1A2 or SULT1A4 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.1cytosol
Human-GEM MAR08534CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+MAM03099cproton+adenosine 3',5'-bismonophosphate+MAM03100c
Catalysed by SULT1A1 or SULT1A2 or SULT1A4 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.1cytosol
Human-GEM MAR08535CC BY 4.0Reference data
a phenol+3'-phosphoadenylyl sulfatean aryl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C2 or SULT1B1 or SULT1C4 or SULT1A3 or SULT1A4 or SULT1A1 or SULT1A2 or SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12164CC BY 4.0Reference data
4-nitrophenol+3'-phosphoadenylyl sulfate4-nitrophenyl sulfate+adenosine 3',5'-bisphosphate
Catalysed by SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:66548CC BY 4.0Reference data
3,3',5-triiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3',5-triiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67876CC BY 4.0Reference data
dopamine+3'-phosphoadenylyl sulfatedopamine 3-O-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67880CC BY 4.0Reference data
dopamine+3'-phosphoadenylyl sulfatedopamine 4-O-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67884CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3',5'-triiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67888CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3'-diiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67892CC BY 4.0Reference data
serotonin+3'-phosphoadenylyl sulfateserotonin O-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1A3 or SULT1A4
Reaction pageLeft to rightBalanced
Rhea RHEA:83339CC BY 4.0Reference data