Compound

(2E)-dodecenoyl-CoA

Tetraanion of trans-dodec-2-enoyl-CoA arising from deprotonation of phosphate and diphosphate functions.

Definition from ChEBI (CHEBI:57330), read 2026-09-23. CC BY 4.0.

CHEBI:57330ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C33H52N7O17P3S
Mass: 943.8 g/mol
Charge: -4
InChIKey: IRFYVBULXZMEDE-DEEZISNZSA-J
SMILES: CCCCCCCCC/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

12 entities

12 entities reached.

0 reported hops12 assembled from the scaffold

What the reference databases state

Statements

48 statements

48 statements · 2 reference databases · Subject: (2E)-dodecenoyl-CoA · Sources: Human-GEM, Rhea

Order

(2E)-dodecenoyl-CoA is converted to (3Z)-dodecenoyl-CoACompoundHuman-GEM MAR03239Inferred only
(3Z)-dodecenoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03239Inferred only
(2E)-dodecenoyl-CoA is converted to (3Z)-dodecenoyl-CoACompoundHuman-GEM MAR03355Inferred only
(3Z)-dodecenoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundRhea RHEA:23716Inferred only
(3Z)-dodecenoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03355Inferred only
(2E)-dodecenoyl-CoA is converted to (5Z)-dodecenoyl-CoACompoundHuman-GEM MAR03375Inferred only
(2E)-dodecenoyl-CoA is converted to (5Z)-dodecenoyl-CoACompoundHuman-GEM MAR03272Inferred only
(5Z)-dodecenoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03272Inferred only
(5Z)-dodecenoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03375Inferred only
dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03086Inferred only
dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR03135Inferred only
(2E)-dodecenoyl-CoA is converted to dodecanoyl-CoACompoundRhea RHEA:44964Inferred only

Show the remaining 36

dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundRhea RHEA:40171Inferred only
dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundRhea RHEA:45408Inferred only
(2E)-dodecenoyl-CoA is converted to dodecanoyl-CoACompoundHuman-GEM MAR02149Inferred only
(2E)-dodecenoyl-CoA is converted to dodecanoyl-CoACompoundRhea RHEA:31039Inferred only
dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundRhea RHEA:31039Inferred only
(2E)-dodecenoyl-CoA is converted to dodecanoyl-CoACompoundRhea RHEA:45408Inferred only
dodecanoyl-CoA is converted to (2E)-dodecenoyl-CoACompoundHuman-GEM MAR02149Inferred only
(2E)-dodecenoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR05069Inferred only
(2E)-dodecenoyl-CoA is a substrate of CPT1AProteinHuman-GEM MAR04508Inferred only
(2E)-dodecenoyl-CoA is a substrate of CPT1BProteinHuman-GEM MAR04508Inferred only
(2E)-dodecenoyl-CoA is a substrate of CPT1CProteinHuman-GEM MAR04508Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECH1ProteinHuman-GEM MAR03239Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECH1ProteinHuman-GEM MAR03272Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECHS1ProteinHuman-GEM MAR03136Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03355Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03375Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03239Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03272Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03087Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03239Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03375Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03272Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03355Inferred only
(2E)-dodecenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03087Inferred only
(2E)-dodecenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR05069Inferred only
(2E)-dodecenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03375Inferred only
(2E)-dodecenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03087Inferred only
(2E)-dodecenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03355Inferred only
(2E)-dodecenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03136Inferred only
(2E)-dodecenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03087Inferred only
(2E)-dodecenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03355Inferred only
(2E)-dodecenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03375Inferred only
(2E)-dodecenoyl-CoA is a substrate of HADHAProteinRhea RHEA:31075Inferred only
(2E)-dodecenoyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR05069Inferred only
(2E)-dodecenoyl-CoA is a substrate of MECRProteinHuman-GEM MAR02149Inferred only
(2E)-dodecenoyl-CoA is a substrate of PECRProteinRhea RHEA:44964Inferred only

Reactions

22 reactions

MAM00935m+CHEBI:1146900(2E)-dodecenoyl-CoA+proton+dioxygen
Reaction pageLeft to rightUnbalancedmitochondrial matrix
Human-GEM MAR01185CC BY 4.0Reference data
MAM00936m+CHEBI:1146900(2E)-dodecenoyl-CoA+proton+dioxygen
Reaction pageLeft to rightUnbalancedmitochondrial matrix
Human-GEM MAR01227CC BY 4.0Reference data
dodecanoyl-CoA+NADP(3-)(2E)-dodecenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02149CC BY 4.0Reference data
FAD+dodecanoyl-CoA(2E)-dodecenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR03086CC BY 4.0Reference data
(2E)-dodecenoyl-CoA+waterMAM00174x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03087CC BY 4.0Reference data
FAD+dodecanoyl-CoA(2E)-dodecenoyl-CoA+FADH2
Catalysed by ACADVL or ACADL or ACADM or ACAD9
Reaction pageLeft to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-, 1.3.3.6mitochondrial matrix
Human-GEM MAR03135CC BY 4.0Reference data
(2E)-dodecenoyl-CoA+waterMAM00174m
Catalysed by HADHA or ECHS1
Reaction pageLeft to rightBalancedEC 1.3.3.6, 4.2.1.17mitochondrial matrix
Human-GEM MAR03136CC BY 4.0Reference data
(2E)-dodecenoyl-CoA(3Z)-dodecenoyl-CoA
Catalysed by ECH1 or ECI1 or ECI2
Reaction pageReversibleBalancedEC 5.3.3.8, 5.3.3.-mitochondrial matrix
Human-GEM MAR03239CC BY 4.0Reference data
(2E)-dodecenoyl-CoA(5Z)-dodecenoyl-CoA
Catalysed by ECH1 or ECI1 or ECI2
Reaction pageReversibleBalancedEC 5.3.3.8, 5.3.3.-mitochondrial matrix
Human-GEM MAR03272CC BY 4.0Reference data
(2E)-dodecenoyl-CoA(3Z)-dodecenoyl-CoA
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageReversibleBalancedEC 5.3.3.8peroxisome
Human-GEM MAR03355CC BY 4.0Reference data
(2E)-dodecenoyl-CoA(5Z)-dodecenoyl-CoA
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageReversibleBalancedEC 5.3.3.8peroxisome
Human-GEM MAR03375CC BY 4.0Reference data
(2E)-dodecenoyl-CoA+(S)-carnitineCHEBI:1146900+MAM03541c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR04508CC BY 4.0Reference data

Show the remaining 10

Other names

1 name

Resolves to: (2E)-dodecenoyl-CoA

Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-dodec-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate}