What the reference databases state

GenCC submitters' classifications

1 row

alkaptonuria has a germline basis in HGDDiseaseGenCC HGNC:4892|MONDO:0008753Inferred only

Statements

32 statements

32 statements · 8 reference databases · Subject: HGD · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

H2BW1 covaries with HGDProteinHetionet hetionet:covaries:158983-3081Inferred only
HGD is expressed in adult mammalian kidneyAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in gallbladderAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in left lobe of thyroid glandAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in liverAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in liverAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in nephron tubuleAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in prostate glandAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in right lobe of liverAnatomyBgee ENSG00000113924Inferred only

Show the remaining 20

HGD is expressed in right lobe of thyroid glandAnatomyBgee ENSG00000113924Inferred only
HGD is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in stomachAnatomyHuman Protein Atlas ENSG00000113924Inferred only
HGD is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000113924Inferred only
CLDN7 interacts with HGDProteinHetionet hetionet:interacts:1366-3081Inferred only
CTBP2 interacts with HGDProteinHetionet hetionet:interacts:1488-3081Inferred only
HGD interacts with GIT2ProteinHetionet hetionet:interacts:3081-9815Inferred only
HGD interacts with PCDHGC3ProteinHetionet hetionet:interacts:3081-5098Inferred only
HGD interacts with TERF1ProteinHetionet hetionet:interacts:3081-7013Inferred only
HGD participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
HGD participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
HGD participates in Phenylalanine and tyrosine metabolismPathwayReactome R-HSA-8963691Inferred only
HGD participates in Tyrosine catabolismPathwayReactome R-HSA-8963684Inferred only
HGD participates in Tyrosine metabolism and related disordersPathwayWikiPathways WP4506Inferred only
EGR1 increases the expression of HGDProteinHetionet hetionet:regulates:1958-3081Inferred only
IARS2 increases the expression of HGDProteinHetionet hetionet:regulates:55699-3081Inferred only
KEAP1 increases the expression of HGDProteinHetionet hetionet:regulates:9817-3081Inferred only
HGD requires the cofactor iron cationCompoundUniProt Q93099Inferred only
homogentisate is a substrate of HGDCompoundRhea RHEA:15449Inferred only
homogentisate is a substrate of HGDCompoundHuman-GEM MAR06774Inferred only

Reactions

2 reactions

homogentisate+dioxygen4-maleylacetoacetic acid+proton
Catalysed by HGD
Reaction pageLeft to rightBalancedEC 1.13.11.5cytosol
Human-GEM MAR06774CC BY 4.0Reference data
homogentisate+dioxygen4-maleylacetoacetate+hydron
Catalysed by HGD
Reaction pageLeft to rightBalanced
Rhea RHEA:15449CC BY 4.0

Other names

4 names

Resolves to: HGD

Also called: HGOHomogentisate oxygenaseHomogentisic acid oxidaseHomogentisicase