Compound
(S)-methylmalonyl-CoA
Pentaanion of (S)-methylmalonyl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions.
Definition from ChEBI (CHEBI:57327), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C25H35N7O19P3S
- Mass
- 862.574 g/mol
- Charge
- -5
- InChIKey
- MZFOKIKEPGUZEN-IBNUZSNCSA-I
- SMILES
- C[C@@H](C(=O)[O-])C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
18 statements
18 statements · 2 reference databases · Subject: (S)-methylmalonyl-CoA · Sources: Human-GEM, Rhea
- (S)-methylmalonyl-CoA is converted to (R)-methylmalonyl-CoACompoundRhea RHEA:20553Inferred only
- (S)-methylmalonyl-CoA is converted to (R)-methylmalonyl-CoACompoundHuman-GEM MAR03213Inferred only
- acryloyl-CoA is converted to (S)-methylmalonyl-CoACompoundRhea RHEA:60252Inferred only
- (S)-methylmalonyl-CoA is converted to acryloyl-CoACompoundRhea RHEA:60252Inferred only
- (S)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:61340Inferred only
- (S)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:21396Inferred only
- propanoyl-CoA is converted to (S)-methylmalonyl-CoACompoundRhea RHEA:21396Inferred only
- propanoyl-CoA is converted to (S)-methylmalonyl-CoACompoundRhea RHEA:23720Inferred only
- propionyl-CoA is converted to (S)-methylmalonyl-CoACompoundHuman-GEM MAR03208Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR01522Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR01521Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR08787Inferred only
Show the remaining 6
- (S)-methylmalonyl-CoA is a substrate of ECHDC1ProteinRhea RHEA:61340Inferred only
- (S)-methylmalonyl-CoA is a substrate of MCEEProteinRhea RHEA:20553Inferred only
- (S)-methylmalonyl-CoA is a substrate of MCEEProteinHuman-GEM MAR03213Inferred only
- (S)-methylmalonyl-CoA is a substrate of MLYCDProteinHuman-GEM MAR08787Inferred only
- (S)-methylmalonyl-CoA is a substrate of MLYCDProteinHuman-GEM MAR01522Inferred only
- (S)-methylmalonyl-CoA is a substrate of MLYCDProteinHuman-GEM MAR01521Inferred only
Reactions
26 reactions
proton+(S)-methylmalonyl-CoAcarbon dioxide+propionyl-CoA
Catalysed by MLYCD
Reaction pageLeft to rightBalancedEC 4.1.1.9cytosol
Human-GEM MAR01521CC BY 4.0Reference data
proton+(S)-methylmalonyl-CoAcarbon dioxide+propionyl-CoA
Catalysed by MLYCD
Reaction pageLeft to rightBalancedEC 4.1.1.9peroxisome
Human-GEM MAR01522CC BY 4.0Reference data
water+(S)-methylmalonyl-CoACHEBI:1146900+proton+MAM02479m
Reaction pageReversibleBalancedEC 3.1.2.17mitochondrial matrix
Human-GEM MAR02146CC BY 4.0Reference data
ATP+hydrogencarbonate+propionyl-CoAADP+proton+(S)-methylmalonyl-CoA+phosphate(3-)
Reaction pageLeft to rightBalancedEC 6.4.1.3mitochondrial matrix
Human-GEM MAR03208CC BY 4.0Reference data
(S)-methylmalonyl-CoA(R)-methylmalonyl-CoA
Catalysed by MCEE
Reaction pageLeft to rightBalancedEC 5.1.99.1mitochondrial matrix
Human-GEM MAR03213CC BY 4.0Reference data
proton+(S)-methylmalonyl-CoAcarbon dioxide+propionyl-CoA
Catalysed by MLYCD
Reaction pageLeft to rightBalancedEC 4.1.1.9mitochondrial matrix
Human-GEM MAR08787CC BY 4.0Reference data
(S)-methylmalonyl-CoA+waterCHEBI:17453+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:17345CC BY 4.0Reference data
(R)-methylmalonyl-CoA(S)-methylmalonyl-CoA
Catalysed by MCEE
Reaction pageRight to leftBalanced
Rhea RHEA:20553CC BY 4.0Reference data
(S)-methylmalonyl-CoA+pyruvatepropanoyl-CoA+oxaloacetate
Reaction pageDirection not assertedBalanced
Rhea RHEA:20764CC BY 4.0Reference data
(S)-methylmalonyl-CoA+sodium(1+)+hydronpropanoyl-CoA+sodium(1+)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:21396CC BY 4.0Reference data
6(S)-methylmalonyl-CoA+propanoyl-CoA+6NADPH(4-)+12hydronCHEBI:16089+6carbon dioxide+6NADP(3-)+7coenzyme A(4-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:23068CC BY 4.0Reference data
propanoyl-CoA+hydrogencarbonate+ATP(4-)(S)-methylmalonyl-CoA+ADP(3-)+hydrogenphosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:23720CC BY 4.0Reference data