L-phenylalanine

Two steps

• N-decanoylglycineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

• D-histidineReach from here →
  1. transport of ornithine and phenylalanine (cytosol to extracellular)
  2. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC7A6, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. transport of histidine and phenylalanine (cytosol to extracellular)
  2. Formation of homocarnosine

  Catalysed by SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC7A5, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC7A5, DPEP1, DPEP2extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC7A5, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. transport of glutamine and phenylalanine (cytosol to extracellular)
  2. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC7A5, PFASextracellular space, cytosol

• kinetensin-(1-8)Reach from here →
  1. Chymase
  2. kinetensin + H2O = kinetensin-(1-8) + L-leucine

  Catalysed by CMA1, ACE2extracellular space

• an N-(fatty acyl)-glycineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. transport of phenylalanine and threonine (cytosol to extracellular)
  2. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC7A5extracellular space, cytosol

• cholineReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC6A14, SLC5A7extracellular space, cytosol

• pyruvateReach from here →
  1. transport of alanine and phenylalanine (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 16 routes

• CHEBI:15570Reach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC7A5, GNMTextracellular space, cytosol

• trimethylenediamineReach from here →
  1. transport of lysine and phenylalanine (cytosol to extracellular)
  2. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of histidine and phenylalanine (cytosol to extracellular)
  2. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC7A6, CARNS1extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. transport of phenylalanine and tyrosine (cytosol to extracellular)
  2. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC7A5, THextracellular space, cytosolOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of glutamine and phenylalanine (cytosol to extracellular)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC7A5, GFPT2, GFPT1extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)
  2. glycyl-tRNA(gly) phosphorylation

  Catalysed by FARSB, FARSAcytosolOne of 2 routes

• sulfateReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-Arginine amidinohydrolase

  Catalysed by SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. transport of alanine and phenylalanine (cytosol to extracellular)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC7A5, SLC7A9, SLC3A1extracellular space, cytosolOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of alanine and phenylalanine (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. transport of phenylalanine and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)

  Catalysed by SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• 2-phenylacetaldehydeReach from here →
  1. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  2. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by DDC, AOC2, AOC1, MAOA and 2 morecytosolOne of 2 routes

• oxaloacetateReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC7A13, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• nitric oxideReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A6, NOS3, NOS1, NOS2extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. transport of ornithine and phenylalanine (cytosol to extracellular)
  2. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC7A6, ACY1extracellular space, cytosol

• anthranilateReach from here →
  1. Transport of L-Kynurenine
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC7A8, KYNUextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of alanine and phenylalanine (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A5, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of methionine and phenylalanine (cytosol to extracellular)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A5, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by CNDP2

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of methionine and phenylalanine (cytosol to extracellular)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A5, AADATextracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of phenylalanine and threonine (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC7A5, SDS, SDSLextracellular space, cytosol

• tryptamineReach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A5, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by GOT2, TAT, KYAT1mitochondrial matrixOne of 4 routes

• enol-phenylpyruvateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by GOT2, TAT, MIFmitochondrial matrix

• CHEBI:16856Reach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC7A5, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. transport of glycine and phenylalanine (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. transport of ornithine and phenylalanine (cytosol to extracellular)
  2. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• CHEBI:17380Reach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A5extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of phenylalanine and proline (cytosol to extracellular)
  2. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A6extracellular space, cytosol, mitochondrial matrix