D-histidine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

207 compounds within 3 steps: 1 in 1, 31 in 2, 175 in 3

One step

L-ornithineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

Two steps

L-homoarginineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
L-leucineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of leucine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes
CHEBI:15699Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of homoserine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
CHEBI:15971Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of histidine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A5, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes
L-citrullineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
Catalysed by SLC25A2, SLC7A9inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 9 routes
L-valineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and valine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-arginineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-Arginine:glycine amidinotransferase
Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 7 routes
N(2)-acetyl-L-ornithineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. N2-Acetyl-L-ornithine amidohydrolase
Catalysed by SLC25A2, ACY1inner side of the membrane, outer side of the membrane, cytosol
CHEBI:16857Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and threonine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-isoleucineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of isoleucine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
CHEBI:17203Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and proline (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-glutamic 5-semialdehydeReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-Ornithine:2-oxo-acid aminotransferase
Catalysed by SLC25A2, OATinner side of the membrane, outer side of the membrane, mitochondrial matrix
L-cysteineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of cysteine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
CHEBI:17895Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and tyrosine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
CHEBI:18019Reach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of lysine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A5, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes
L-glutamineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of glutamine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-lysineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
Catalysed by SLC25A2, SLC25A15inner side of the membrane, outer side of the membraneOne of 2 routes
D-lysineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
putrescineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine carboxy-lyase (putrescine-forming)
Catalysed by SLC25A2, ODC1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes
D-arginineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
glycineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-Arginine:glycine amidinotransferase
Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes
L-histidineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
D-ornithineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
L-methionineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of methionine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-tryptophanReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and tryptophan (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-alanineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of alanine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes
L-asparagineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of asparagine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-glutamate 5-semialdehydeReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
Catalysed by SLC25A2, OATinner side of the membrane, outer side of the membrane
L-phenylalanineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and phenylalanine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
5-amino-2-oxopentanoateReach from here →
1. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes

Three steps

beta-carbolineReach from here →
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol
CHEBI:1146900Reach from here →
Catalysed by