leukotriene C4

Three steps

• sphing-4-enineReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 1 morecytosol, peroxisome, Golgi apparatusOne of 2 routes

• D-threonineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• spermidineReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by BAAT, SAT1, SAT2cytosol, peroxisomeOne of 3 routes

• L-dopaquinoneReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by SLC7A5, TYRcytosol, extracellular spaceOne of 2 routes

• L-threonineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-saccharopineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and lysine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by SLC7A6, AASScytosol, extracellular space, mitochondrial matrix

• L-kynurenineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, KYNUcytosol, extracellular spaceOne of 5 routes

• beta-alanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC6A6cytosol, extracellular spaceOne of 4 routes

• dimethylamineReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by AGXT2, DDAH1cytosolOne of 2 routes

• taurocyamineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by SLC7A6, GATMcytosol, extracellular space

• L-glutamate 5-semialdehydeReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by GATM, OATcytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, KYNUcytosol, extracellular space

• porphobilinogenReach from here →
  1. leukotriene C4 hydrolysis
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
  3. 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing

  Catalysed by ALAS1, ALAS2, CPNE7, ALADcytosol, mitochondrial matrixOne of 2 routes

• L,L-cystathionineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. L-serine hydro-lyase (adding homocysteine

  Catalysed by SLCO1B1, CBSextracellular space, cytosolOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SLCO1B1, GCLC, GCLMextracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and lysine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by SLC7A6cytosol, extracellular space, peroxisome

• L-homocysteineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A5, BHMT2cytosol, extracellular space

• carbamoyl phosphateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by SLC7A5, CADcytosol, extracellular spaceOne of 4 routes

• N,N-dimethylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
  3. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]

  Catalysed by PIPOX, DMGDHcytosol

• S-methyl-L-methionineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A5, BHMT2cytosol, extracellular space

• an acyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 1 morecytosol, peroxisome, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SLC1A4cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 3 routes

• L-2-aminopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AGXT2cytosol

• kynurenateReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

  Catalysed by AADAT, KYAT3cytosol

• L-2-aminohexanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by AGXT2cytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. leukotriene C4 hydrolysis
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by SHMT1, ATICcytosol

• 5-guanidino-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by SLC7A6, IL4I1cytosol, extracellular space

• (3Z)-dodecenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by BAAT, HADHA, ACAA2, HADHBcytosol, peroxisome, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLCO1B1, CARS2extracellular space, cytosol

• N(tau)-methylhistamineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HNMTextracellular space, cytosolOne of 3 routes

• N-formyl-L-kynurenineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC7A5, IDO1, TDO2, IDO2cytosol, extracellular space

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by BAAT, SLC27A2, SLC27A5cytosol, peroxisome, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC7A5, PPATcytosol, extracellular spaceOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC7A5, GFPT2, GFPT1cytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A5, MSRAcytosol, extracellular space

• L-methionine (R)-S-oxideReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A5, MSRB3, MSRB1, MSRB2cytosol, extracellular space

• 5-amino-2-oxopentanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by GATM, AGXT2cytosolOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by BAAT, SLC27A2, SLC27A5cytosol, peroxisomeOne of 4 routes

• hyodeoxycholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

• methylamineReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
  3. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

  Catalysed by AGXT2, DDAH1cytosol

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLCO1B1, PPCSextracellular space, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 25 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. leukotriene C4 hydrolysis
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by AADAT, PAHcytosol

• 4-aminobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC7A5, TPOcytosol, extracellular spaceOne of 2 routes

• L-prolineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SLC1A4cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 3 routes

• 3-sulfino-L-alanineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLCO1B1, CDO1extracellular space, cytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by BAAT, ACSM4, ACSM1, ACSM2A and 3 morecytosol, peroxisomeOne of 8 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by BAAT, CPT1A, CPT1C, CPT1Bcytosol, peroxisomeOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, peroxisomeOne of 11 routes