gamma-L-glutamyl-L-cysteine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

578 compounds within 3 steps: 4 in 1, 123 in 2, 451 in 3

One step

CHEBI:16856Reach from here →
1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
Catalysed by GSScytosol
L-cysteineReach from here →
1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
Catalysed by GGCT, GGACTcytosol
CHEBI:18183Reach from here →
1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
Catalysed by GGCT, GGACTcytosol
glutathioneReach from here →
1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by GSS

Two steps

CHEBI:1146900Reach from here →
1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by GGCT, GGACT, NAGScytosol, mitochondrial matrix
2-phenylpropan-2-olReach from here →
1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
Catalysed by GSS, CLIC2, GPX1, GPX2 and 1 more

a hydroxy polyunsaturated fatty acid

Reach from here →

Catalysed by GSS, GPX1, GPX2, GPX4

AReach from here →

Catalysed by GGCT, GGACT, MOCOScytosol

tauroursodeoxycholateReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

glycoursodeoxycholateReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by GSS, GPX1, GPX4

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by GSS, PTGES, MGST3, GSTA4 and 18 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by GSScytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by GSS, GSTA1, GSTM1

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by GSS, GSTP1, GSTM1

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by GSS, GSTA1, GSTP1, GSTM1

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by GSS, GSTP1, GSTM1

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by GSS, PTGES, LANCL1, GSTM4 and 1 more

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by GSS, GSTM4, LTC4S

S-methyl glutathioneReach from here →

Catalysed by GSS, MMACHC

S-adenosylglutathioneReach from here →

Catalysed by GSS, MMACHC

acetylcholineReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by GGCT, GGACT, CTHcytosolOne of 2 routes

L-leucineReach from here →

Catalysed by GGCT, GGACT, SLC7A9, SLC3A1cytosol, extracellular spaceOne of 3 routes

CHEBI:15650Reach from here →

Catalysed by GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes

CHEBI:15699Reach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 3 routes

bromideReach from here →

Catalysed by GSS, MGST3, GSTA4, GSTA1 and 14 morecytosolOne of 2 routes

CHEBI:15971Reach from here →

Catalysed by GGCT, GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

a halide anionReach from here →

Catalysed by GSS, GSTT4, GSTA4, GSTZ1 and 20 more

L-cystineReach from here →

Catalysed by GGCT, GGACT, TXNRD1, TXNRD3 and 1 morecytosolOne of 4 routes

lithocholic acidReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

L-citrullineReach from here →

Catalysed by GGCT, GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-valineReach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-arginineReach from here →

Catalysed by GGCT, GGACT, SLC7A6cytosol, extracellular spaceOne of 5 routes

protein polypeptide chainReach from here →

Catalysed by GGCT, GGACTcytosol

CHEBI:16857Reach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 4 routes

bilirubin IXalphaReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

L-isoleucineReach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 4 routes

CHEBI:17203Reach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:17208Reach from here →

Catalysed by GSScytosol

homocysteineReach from here →

Catalysed by GSScytosol

sulfiteReach from here →

Catalysed by GSS, TSTD1One of 2 routes

urateReach from here →

Catalysed by GSS, SLC22A13inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by GSS, GSTO1, GSTO2

CHEBI:17895Reach from here →

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular spaceOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by GGCT, GGACT, SLC7A6cytosol, extracellular spaceOne of 2 routes