Compound
carbamoyl phosphate
The monoanhydride of carbamic acid with phosphoric acid. It is an important intermediate metabolite and is synthesized enzymatically by carbamyl-phosphate synthase (ammonia) and carbamoyl-phosphate synthase (glutamine-hydrolyzing).
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- CH2NO5P
- Mass
- 139.003 g/mol
- Charge
- -2
- InChIKey
- FFQKYPRQEYGKAF-UHFFFAOYSA-L
- SMILES
- NC(=O)OP(=O)([O-])[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- CADProteinUNIPROT:P27708substrate ofInferred only108 paths27 endpoints
- L-glutamineCompoundCHEBI:18050converted toInferred only47 paths26 endpoints
- OTCProteinUNIPROT:P00480substrate ofInferred only20 paths20 endpoints
- CPS1ProteinUNIPROT:P31327substrate ofInferred only16 paths16 endpoints
- G6PC2ProteinUNIPROT:Q9NQR9substrate ofInferred only7 paths7 endpoints
What the reference databases state
Statements
10 statements
10 statements · 2 reference databases · Subject: carbamoyl phosphate · Sources: Human-GEM, Rhea
- carbamoyl phosphate is converted to L-glutamineCompoundRhea RHEA:18633Inferred only
- L-glutamine is converted to carbamoyl phosphateCompoundHuman-GEM MAR04034Inferred only
- L-glutamine is converted to carbamoyl phosphateCompoundRhea RHEA:18633Inferred only
- carbamoyl phosphate is a substrate of CADProteinRhea RHEA:20013Inferred only
- carbamoyl phosphate is a substrate of CADProteinHuman-GEM MAR04050Inferred only
- carbamoyl phosphate is a substrate of CADProteinRhea RHEA:18029Inferred only
- carbamoyl phosphate is a substrate of CADProteinRhea RHEA:18633Inferred only
- carbamoyl phosphate is a substrate of CPS1ProteinRhea RHEA:18029Inferred only
- carbamoyl phosphate is a substrate of G6PC2ProteinHuman-GEM MAR08652Inferred only
- carbamoyl phosphate is a substrate of OTCProteinHuman-GEM MAR03809Inferred only
Reactions
25 reactions
L-citrulline+proton+phosphate(3-)carbamoyl phosphate+L-ornithine
Catalysed by OTC
Reaction pageReversibleBalancedEC 2.1.3.3mitochondrial matrix
Human-GEM MAR03809CC BY 4.0Reference data
2ATP+carbon dioxide+water+ammonium2ADP+carbamoyl phosphate+2proton+phosphate(3-)
Catalysed by CPS1
Reaction pageLeft to rightBalancedEC 6.3.4.16mitochondrial matrix
Human-GEM MAR03873CC BY 4.0Reference data
2ATP+L-glutamine+water+hydrogencarbonate2ADP+carbamoyl phosphate+L-glutamate(1-)+2proton+phosphate(3-)
Catalysed by CAD
Reaction pageLeft to rightBalancedEC 6.3.5.5cytosol
Human-GEM MAR04034CC BY 4.0Reference data
proton+N-carbamoyl-L-aspartic acid+phosphate(3-)L-aspartate+carbamoyl phosphate
Catalysed by CAD
Reaction pageReversibleBalancedEC 2.1.3.2cytosol
Human-GEM MAR04050CC BY 4.0Reference data
carbamoyl phosphate+phosphate(3-)+diphosphate(3-)carbamoyl phosphate+phosphate(3-)+diphosphate(3-)
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08651CC BY 4.0Reference data
carbamoyl phosphate+D-glucosecarbon dioxide+D-glucopyranose 6-phosphate+ammonium
Catalysed by G6PC2
Reaction pageLeft to rightBalancedEC 3.1.3.9endoplasmic reticulum
Human-GEM MAR08652CC BY 4.0Reference data
2ATP+hydrogencarbonate+ammonium2ADP+carbamoyl phosphate+proton+phosphate(3-)
Catalysed by CPS1
Reaction pageLeft to rightBalancedEC 6.3.4.16mitochondrial matrix
Human-GEM MAR08654CC BY 4.0Reference data
carbamoyl phosphate+CHEBI:18019proton+phosphate(3-)+MAM03681c
Reaction pageReversibleBalancedEC 2.1.3.8cytosol
Human-GEM MAR09940CC BY 4.0Reference data
hydrogencarbonate+ammonium+ATP(4-)carbamoyl phosphate+ADP(3-)+water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:10152CC BY 4.0Reference data
carbamoyl phosphate+L-lysineCHEBI:58148+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:17121CC BY 4.0Reference data
hydrogencarbonate+ammonium+2ATP(4-)carbamoyl phosphate+2ADP(3-)+hydrogenphosphate+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:18029CC BY 4.0Reference data
N(2)-acetyl-L-ornithine+carbamoyl phosphateCHEBI:58765+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:18609CC BY 4.0Reference data
Other names
1 name
Resolves to: carbamoyl phosphate
- Also called
- carbamoyl phosphate dianion