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Proteins/UNIPROT:Q9Y3D2
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance..
Function from UniProtKB (Q9Y3D2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
110 statements
110 statements · 7 reference databases · Subject: MSRB2 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
2 reactions
[thioredoxin]-disulfide+L-methionine+waterL-methionine (R)-S-oxide+[thioredoxin]-dithiol
Catalysed by MSRB3 or MSRB1 or MSRB2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21260CC BY 4.0Reference data
L-methionyl-[protein]+[thioredoxin]-disulfide+waterL-methionyl-(R)-S-oxide-[protein]+[thioredoxin]-dithiol
Catalysed by MSRB3
2 names
Resolves to: MSRB2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24164CC BY 4.0Reference data