Loading the page.
Proteins/UNIPROT:P14679
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone..
Function from UniProtKB (P14679), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
6 rows
29 statements
29 statements · 7 reference databases · Subject: TYR · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
14 reactions
MAM02138g+dioxygenwater+MAM02499g
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1Golgi apparatus
Human-GEM MAR03613CC BY 4.0Reference data
MAM02138l+dioxygenwater+MAM02499l
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1lysosome
Human-GEM MAR03614CC BY 4.0Reference data
1 paper
4 names
Resolves to: TYR
Catalysed by TYR
Reaction pageLeft to rightUnbalancedEC 1.14.18.1cytosol
Human-GEM MAR06729CC BY 4.0Reference data
MAM02138c+dioxygenwater+MAM02499c
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR06803CC BY 4.0Reference data
dioxygen+CHEBI:17895water+L-dopaquinone
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR06874CC BY 4.0Reference data
MAM01053c+dioxygenMAM01059c+hydrogen peroxide
Reaction pageLeft to rightBalancedEC 1.1.3.-, 1.14.18.1cytosol
Human-GEM MAR06889CC BY 4.0Reference data
2MAM00638c+dioxygen2water+2MAM02355c
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR08533CC BY 4.0Reference data
dioxygen+2CHEBI:178952CHEBI:15765
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR08541CC BY 4.0Reference data
2CHEBI:15765+dioxygen2water+2L-dopaquinone
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR08542CC BY 4.0Reference data
2dopamine+dioxygen2dopamine quinone+2water
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR12004CC BY 4.0Reference data
25,6-dihydroxyindole+dioxygen2water+2MAM03163c
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1cytosol
Human-GEM MAR12024CC BY 4.0Reference data
L-tyrosine+dioxygenL-dopaquinone+water
Catalysed by TYR
Reaction pageLeft to rightBalanced
Rhea RHEA:18117CC BY 4.0Reference data