N-formyl-L-kynurenine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

256 compounds within 3 steps: 3 in 1, 46 in 2, 207 in 3

One step

formateReach from here →
1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
Catalysed by AFMID
L-tryptophanReach from here →
1. L-tryptophan + O2 = N-formyl-L-kynurenine
Catalysed by IDO1, TDO2, IDO2
L-kynurenineReach from here →
1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
Catalysed by AFMID

Two steps

beta-carbolineReach from here →
1. L-tryptophan + O2 = N-formyl-L-kynurenine
2. beta-carboline hydrolysis
Catalysed by IDO1, TDO2, IDO2cytosol
4a-hydroxytetrahydrobiopterinReach from here →
1. L-tryptophan + O2 = N-formyl-L-kynurenine
2. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
Catalysed by IDO1, TDO2, IDO2, TPH1 and 1 morecytosol

Three steps

(S)-carnitineReach from here →
Catalysed by IDO1, TDO2, IDO2, SLC6A14extracellular space, cytosol

L-leucine

Reach from here →

Catalysed by AFMID, SLC43A1extracellular space, cytosolOne of 7 routes

(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →

Catalysed by IDO1, TDO2, IDO2, TPH1 and 1 more

CHEBI:15699Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 3 routes

CHEBI:15971Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A6extracellular space, cytosolOne of 2 routes

L-citrullineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A9 and 2 moreextracellular space, cytosol

L-valineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 4 routes

L-arginineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A6extracellular space, cytosolOne of 2 routes

protein polypeptide chainReach from here →

Catalysed by IDO1, TDO2, IDO2cytosol

anthranilateReach from here →

Catalysed by AFMID, KYNU

tryptamineReach from here →

Catalysed by IDO1, TDO2, IDO2, DDCcytosol

formaldehydeReach from here →

Catalysed by AFMID, ALDH9A1

CHEBI:16857Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 4 routes

L-isoleucineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 4 routes

CHEBI:17203Reach from here →

Catalysed by IDO1, TDO2, IDO2, ABCA1 and 1 moreextracellular space, cytosolOne of 4 routes

CHEBI:17380Reach from here →

Catalysed by AFMID, KMOcytosolOne of 3 routes

L-cysteineReach from here →

Catalysed by AFMID, AADATOne of 5 routes

indole-3-pyruvateReach from here →

Catalysed by IDO1, TDO2, IDO2, IL4I1One of 2 routes

5-hydroxy-L-tryptophanReach from here →

Catalysed by IDO1, TDO2, IDO2, TPH1 and 1 more

CHEBI:17895Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A6extracellular space, cytosolOne of 2 routes

L-glutamineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 4 routes

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by AFMID, MTHFD1, MTHFD1L

5-hydroxytryptophanReach from here →

Catalysed by IDO1, TDO2, IDO2, TPH1 and 1 morecytosolOne of 2 routes

Trp-tRNA(Trp)Reach from here →

Catalysed by IDO1, TDO2, IDO2, WARS1cytosol

chlorine(.)Reach from here →

Catalysed by IDO1, TDO2, IDO2, SLC6A14extracellular space, cytosolOne of 2 routes

L-aspartateReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:30249Reach from here →

Catalysed by IDO1, TDO2, IDO2cytosol

oxalateReach from here →

Catalysed by AFMID, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

anthranilic acidReach from here →

Catalysed by AFMID, KYNUcytosol

L-ornithineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A6extracellular space, cytosolOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

Catalysed by AFMID, ADI1One of 2 routes

glycineReach from here →

Catalysed by AFMID, KYAT3, AADATOne of 6 routes

S-formylglutathioneReach from here →

Catalysed by AFMID, ESD

L-methionineReach from here →

Catalysed by AFMID, AADATOne of 5 routes

L-alanineReach from here →

Catalysed by AFMID, KYNUcytosolOne of 6 routes

L-asparagineReach from here →

Catalysed by IDO1, TDO2, IDO2, SLC7A5extracellular space, cytosolOne of 3 routes

L-phenylalanineReach from here →

Catalysed by AFMID, SLC7A8extracellular space, cytosolOne of 9 routes

3-hydroxy-L-kynurenineReach from here →

Catalysed by AFMID, KMO

L-2-aminopentanoateReach from here →

Catalysed by AFMID, AADAT

kynurenateReach from here →

Catalysed by AFMID, KYAT3, AADATmitochondrial matrixOne of 13 routes

L-2-aminohexanoateReach from here →

Catalysed by AFMID, AADAT

L-2-aminoadipateReach from here →

Catalysed by AFMID, AADAT

an L-alpha-amino acidReach from here →

Catalysed by AFMID, SLC7A11inner side of the membrane, outer side of the membraneOne of 2 routes

(2S)-2-aminobutanoateReach from here →

Catalysed by AFMID, AADAT