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Proteins/UNIPROT:P48506
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis..
Function from UniProtKB (P48506), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
125 statements
125 statements · 7 reference databases · Subject: GCLC · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+L-cysteine+L-glutamate(1-)ADP+gamma-L-glutamyl-L-cysteine+proton+phosphate(3-)
Reaction pageLeft to rightBalancedEC 6.3.2.2cytosol
Human-GEM MAR04324CC BY 4.0Reference data
5 names
Resolves to: GCLC
Catalysed by GCLC
Reaction pageLeft to rightBalanced
Rhea RHEA:13285CC BY 4.0Reference data
(2S)-2-aminobutanoate+L-glutamate(1-)+ATP(4-)gamma-L-glutamyl-(2S)-2-aminobutanoate+ADP(3-)+hydrogenphosphate+hydron
Catalysed by GCLC
Reaction pageLeft to rightBalanced
Rhea RHEA:72067CC BY 4.0Reference data