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Proteins/UNIPROT:Q9HAB8
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate..
Function from UniProtKB (Q9HAB8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
55 statements
55 statements · 5 reference databases · Subject: PPCS · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
4 reactions
CHEBI:17677+L-cysteine+(R)-4'-phosphopantothenateN-[(R)-4-phosphopantothenoyl]-L-cysteine+cytidine 5'-monophosphate+proton+diphosphate(3-)
Catalysed by PPCS
Reaction pageLeft to rightBalancedEC 6.3.2.5cytosol
Human-GEM MAR04723CC BY 4.0Reference data
3 names
Resolves to: PPCS
Catalysed by PPCS
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR11416CC BY 4.0Reference data
(R)-4'-phosphopantothenate+L-cysteine+CTPN-[(R)-4-phosphopantothenoyl]-L-cysteine+CMP+diphosphate(3-)+hydron
Catalysed by PPCS
Reaction pageLeft to rightBalanced
Rhea RHEA:19397CC BY 4.0Reference data
(R)-4'-phosphopantothenate+L-cysteine+ATP(4-)N-[(R)-4-phosphopantothenoyl]-L-cysteine+AMP+diphosphate(3-)+hydron
Catalysed by PPCS
Reaction pageLeft to rightBalanced
Rhea RHEA:25156CC BY 4.0Reference data