thiosulfate

Three steps

• L-tryptophanReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 8 routes

• beta-alanineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 36 routes

• leukotriene C4Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by TSTD1, MGST3, GSTM4, LTC4S and 1 morecytosolOne of 5 routes

• L-asparagineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 8 routes

• IMPReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

  Catalysed by SLC25A10, ADSL, TNRC6B, ADSS2 and 1 moremitochondrial matrix, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A14, SLC25A30, AGAcytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 10 routes

• 3',5'-cyclic AMPReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by CBS, GCLC, GCLMcytosolOne of 2 routes

• taurolithocholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-tyrosineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A14, SLC25A30, AGXT2cytosol, inner side of the membrane, outer side of the membrane

• trans-4-hydroxy-L-prolineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SQOR, PRODH2cytosol

• 5-oxo-L-prolineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by TSTD1, CHAC2, CHAC1cytosol

• histamineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• kynurenateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by MPST, AADATcytosolOne of 4 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A10, ADSLmitochondrial matrix, cytosolOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by CBS, CARS2cytosol

• (3S)-citramalyl-CoAReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by MPST, TST, CLYBLmitochondrial matrix, cytosol

• phosphoenolpyruvateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• D-glucosamineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SGSHcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by CBS, PPCScytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A12cytosol, extracellular spaceOne of 4 routes

• dopamineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-prolineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SQOR, PRODH, PRODH2cytosol

• prostaglandin E2Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• N-benzoylglycineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC25A35, SLC25A34, SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by CBS, CDO1cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glutathione + H2O = L-cysteinylglycine + L-glutamate

  Catalysed by TSTD1, GGT3P, GGT1, GGT5 and 2 morecytosolOne of 6 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MPST, TST, HOGA1mitochondrial matrix, cytosolOne of 2 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, PRODH2mitochondrial matrix, cytosol

• 3-demethylubiquinol-10Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SQOR, COQ3cytosol

• xanthurenateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by SLC25A10, CLYBL, KYAT3, AADATmitochondrial matrix, cytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MPST, TST, HOGA1mitochondrial matrix, cytosolOne of 2 routes

• (R)-noradrenalineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• beta-citrylglutamateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A10, SLC25A1, RIMKLBmitochondrial matrix, cytosol

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4cytosol

• ursodeoxycholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• thio-Mo-molybdopterinReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CBS, MOCOScytosol

• glycodeoxycholateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX2, GPX4cytosol

• a methyl thioetherReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SUMF1, TMT1B, TMT1Acytosol

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by STS, CYP3A7cytosol