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Proteins/UNIPROT:Q9NZJ6
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis (By similarity). Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid (By similarity). Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone (By similarity). Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10 (By similarity)..
Function from UniProtKB (Q9NZJ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 7 reference databases · Subject: COQ3 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
S-adenosyl-L-methionine+3-demethylubiquinone-10proton+CHEBI:16680+ubiquinones
Catalysed by COQ3
Reaction pageLeft to rightBalancedEC 2.1.1.-mitochondrial matrix
Human-GEM MAR00131CC BY 4.0Reference data
3,4-dihydroxy-5-(all-trans-decaprenyl)benzoate+S-adenosyl-L-methionine4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoate+proton+CHEBI:16680
Catalysed by
3 names
Resolves to: COQ3
Reaction pageLeft to rightBalancedEC 2.1.1.114mitochondrial matrix
Human-GEM MAR06905CC BY 4.0Reference data
3-demethylubiquinol-10+S-adenosyl-L-methionineproton+CHEBI:16680+ubiquinol
Catalysed by COQ3
Reaction pageLeft to rightBalancedEC 2.1.1.64mitochondrial matrix
Human-GEM MAR06910CC BY 4.0Reference data
3-demethylubiquinol-10+S-adenosyl-L-methionineubiquinol-10+S-adenosyl-L-homocysteine+hydron
Catalysed by COQ3
Reaction pageDirection not assertedBalanced
Rhea RHEA:44412CC BY 4.0Reference data
3,4-dihydroxy-5-(all-trans-decaprenyl)benzoate+S-adenosyl-L-methionine4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoate+S-adenosyl-L-homocysteine+hydron
Catalysed by COQ3
Reaction pageDirection not assertedBalanced
Rhea RHEA:44492CC BY 4.0Reference data
a 3-demethylubiquinone+S-adenosyl-L-methioninea ubiquinone+S-adenosyl-L-homocysteine
Catalysed by COQ3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:81215CC BY 4.0Reference data