(4R)-4-hydroxy-2-oxoglutarate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

269 compounds within 3 steps: 2 in 1, 58 in 2, 209 in 3

One step

pyruvateReach from here →
1. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by HOGA1
glyoxylateReach from here →
1. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by HOGA1

Two steps

2-hydroxybutyric acidReach from here →
1. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes
acetoacetateReach from here →
1. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
Catalysed by HOGA1mitochondrial matrix, cytosolOne of 4 routes

N-octanoyl-(2S)-hydroxyglycine

Reach from here →

Catalysed by HOGA1, PAM

N-decanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by HOGA1, PAM

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by HOGA1, PAM

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by HOGA1, PAM

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

Catalysed by HOGA1, PAM

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

Catalysed by HOGA1, PAM

acetylpyruvateReach from here →

Catalysed by HOGA1, FAHD1

all-trans-retinoic acidReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

(S)-malateReach from here →

Catalysed by HOGA1, ME2One of 3 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by HOGA1, AGXT2mitochondrial matrix

oxaloacetateReach from here →

Catalysed by HOGA1, PCmitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

Catalysed by HOGA1, LDHA, LDHB, LDHC and 2 more

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by HOGA1, AADAT

2-oxobutanoateReach from here →

Catalysed by HOGA1, AGXT2One of 2 routes

2-oxoglutaramateReach from here →

Catalysed by HOGA1, KYAT1cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by HOGA1, FAHD1

(R)-3-hydroxybutyric acidReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

3-hydroxypyruvateReach from here →

Catalysed by HOGA1, AGXT

aceneuramateReach from here →

Catalysed by HOGA1, NPL

5'-deoxyadenosineReach from here →

Catalysed by HOGA1, TYW1B, TYW1

indole-3-pyruvateReach from here →

Catalysed by HOGA1, AADAT

4-methyl-2-oxopentanoateReach from here →

Catalysed by HOGA1, AADAT

3-phenylpyruvateReach from here →

Catalysed by HOGA1, AADAT

dTDPReach from here →

Catalysed by HOGA1, PKM, PKLRcytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by HOGA1, AGXT2One of 2 routes

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by HOGA1, AGXT2One of 2 routes

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by HOGA1, AGXT2One of 2 routes

glycolateReach from here →

Catalysed by HOGA1, GRHPR

acetateReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 2 moreextracellular space, cytosolOne of 2 routes

oxalateReach from here →

Catalysed by HOGA1, HAO1

formic acidReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A7 and 2 moreextracellular space, cytosolOne of 2 routes

propionic acidReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

butyric acidReach from here →

Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

3-hydroxypyruvic acidReach from here →

Catalysed by HOGA1, AGXTcytosolOne of 2 routes

3-oxopropanoateReach from here →

Catalysed by HOGA1, AGXT2

D-serineReach from here →

Catalysed by HOGA1, SRR

3-(4-hydroxyphenyl)pyruvateReach from here →

Catalysed by HOGA1, AADAT

(R)-lactic acidReach from here →

Catalysed by HOGA1, LDHDcytosol

(S)-lactic acidReach from here →

Catalysed by HOGA1, LDHB, LDHAL6Bmitochondrial matrixOne of 5 routes

2-iminopropanoateReach from here →

Catalysed by HOGA1, RIDA

phosphoenolpyruvic acidReach from here →

Catalysed by HOGA1, PKM, PKLRcytosol

N-acetyl-beta-neuraminic acidReach from here →

Catalysed by HOGA1, NPLcytosol

a 3-acylpyruvateReach from here →

Catalysed by HOGA1, FAHD1

glycineReach from here →

Catalysed by HOGA1, AADATOne of 15 routes

2-oxoadipateReach from here →

Catalysed by HOGA1, AADAT

2-oxo-3-sulfanylpropanoateReach from here →

Catalysed by HOGA1, MPST