L-glutamic 5-semialdehyde

Three steps

• 4-methyl-2-oxopentanoateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by OAT, SLC7A6, BCAT2mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by OAT, GATM, SLC3A2, SLC7A6mitochondrial matrix, cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by OAT, SLC7A6, GOT2, TATmitochondrial matrix, extracellular space, cytosolOne of 5 routes

• fumaric acidReach from here →
  1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
  2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by ALDH4A1, PRODH, PRODH2, SDHBcytosol

• CHEBI:18095Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by OAT, SLC7A6, SLC1A4mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by OAT, GATM, GARTmitochondrial matrix, cytosol

• 2-phenylethylamineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by OAT, SLC7A6, DDCmitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by OAT, SLC7A6, PFASmitochondrial matrix, extracellular space, cytosol

• ophthalmateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by OAT, GATM, GSSmitochondrial matrix, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by OAT, SLC7A6, SLC7A8mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Xaa-L-Pro dipeptideReach from here →
  1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
  2. L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by ALDH4A1, PYCR1, PYCR3, PYCR2 and 1 morecytosol

• biocytinReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by OAT, SLC25A2, SLC25A15, BTDmitochondrial matrix, inner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by OAT, SLC25A2, AGXT2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by OAT, GATM, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by OAT, GATM, SHMT1mitochondrial matrix, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by OAT, SLC7A6, CARS2mitochondrial matrix, extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by OAT, GATM, GLYAT, GLYATL2 and 1 moremitochondrial matrix, cytosol

• a quinolReach from here →
  1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
  2. L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by ALDH4A1, PYCR1, PYCR3, PYCR2 and 2 morecytosolOne of 13 routes

• phenylacetylglycineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by OAT, GATM, GLYATmitochondrial matrix, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by OAT, SLC7A6, TPH1, TPH2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. LTD4 hydrolysis

  Catalysed by OAT, GATMmitochondrial matrix, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by OAT, SLC7A6, SCLYmitochondrial matrix, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by OAT, SLC7A6, NAGSmitochondrial matrix, extracellular space, cytosol

• K(+)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by OAT, SLC7A6, SLC1A1mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, CARS1mitochondrial matrix, extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, FARSB, FARSAmitochondrial matrix, extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by OAT, GATM, GARS1mitochondrial matrix, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, WARS1mitochondrial matrix, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, IARS1mitochondrial matrix, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, QARS1mitochondrial matrix, extracellular space, cytosol

• isocyanateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by OAT, SLC7A9, LACC1mitochondrial matrix, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, NARS1mitochondrial matrix, extracellular space, cytosol

• chlorine(.)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by OAT, GATM, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 31 routes

• glycocholateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by OAT, GATM, BAATmitochondrial matrix, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by OAT, SLC7A6, CTHmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by OAT, SLC7A6, AGXT2mitochondrial matrix, extracellular space, cytosolOne of 19 routes

• acetateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by OAT, ACY1mitochondrial matrix, cytosol

• CHEBI:30249Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by OAT, SLC7A6, IDO1, TDO2 and 1 moremitochondrial matrix, extracellular space, cytosol

• orotateReach from here →
  1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
  2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by ALDH4A1, PRODH, PRODH2, DHODHcytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by OAT, SLC7A6, IL4I1mitochondrial matrix, extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by OAT, SLC7A6, NDUFAB1, FDXR and 5 moremitochondrial matrix, extracellular space, cytosol

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by OAT, SLC7A6, BCAT2, BCAT1mitochondrial matrix, extracellular space, cytosol

• D-cysteineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by OAT, GATM, ALAS1, ALAS2mitochondrial matrix, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by OAT, SLC7A6, BCAT1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by OAT, SLC7A6, GOT2, GOT1 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by OAT, GATM, BAATmitochondrial matrix, cytosol

• glycochenodeoxycholic acidReach from here →
  1. L-Ornithine:2-oxo-acid aminotransferase
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by OAT, GATM, BAATmitochondrial matrix, cytosol, peroxisomeOne of 3 routes