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Proteins/UNIPROT:Q9Y619
Mitochondrial ornithine-citrulline antiporter (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable). Lysine and arginine are also transported by the antiport mechanism (Probable). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity)..
Function from UniProtKB (Q9Y619), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
127 statements
127 statements · 5 reference databases · Subject: SLC25A15 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
18 reactions
L-arginine+protonL-arginine+proton
Transported by SLC25A15 or SLC25A2
Reaction pageReversibleBalancedEC 4.3.2.1cytosol, mitochondrial matrix
Human-GEM MAR00079CC BY 4.0Reference data
Transported by SLC25A15 or SLC25A2
Reaction pageReversibleBalancedEC 3.2.1.14mitochondrial matrix, cytosol
4 names
Resolves to: SLC25A15
proton+L-ornithineproton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05105CC BY 4.0Reference data
proton+CHEBI:18019+L-ornithineproton+CHEBI:18019+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR06301CC BY 4.0Reference data
proton+CHEBI:18019+L-ornithineproton+CHEBI:18019+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, cytosol, mitochondrial matrix
Human-GEM MAR06302CC BY 4.0Reference data
L-arginine+proton+L-ornithineL-arginine+proton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR06307CC BY 4.0Reference data
L-arginine+proton+L-ornithineL-arginine+proton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR06308CC BY 4.0Reference data
proton+CHEBI:15971+L-ornithineproton+CHEBI:15971+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR06313CC BY 4.0Reference data
L-citrulline+proton+L-ornithineL-citrulline+proton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR06317CC BY 4.0Reference data
L-citrulline+proton+L-ornithineL-citrulline+proton+L-ornithine
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR06318CC BY 4.0Reference data
proton+CHEBI:18019proton+CHEBI:18019
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR06321CC BY 4.0Reference data
L-arginine+protonL-arginine+proton
Transported by SLC25A15 or SLC25A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR06323CC BY 4.0Reference data