3-sulfinopyruvate

Three steps

• a halide anionReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by TSTD1, GSTT4, GSTA4, GSTZ1 and 20 morecytosol

• CHEBI:16174Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by PKM, PKLR, NME4, NME6 and 4 morecytosolOne of 3 routes

• L-cystineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by AGXT2, SLC7A9, SLC3A1cytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• CHEBI:16284Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by PKM, PKLR, DTYMKcytosol, mitochondrial matrixOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by AGXT2, ABATcytosol, mitochondrial matrixOne of 3 routes

• L-citrullineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• ubiquinonesReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A10, SDHD, SDHB, SDHA and 1 morecytosol, mitochondrial matrix

• L-valineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• L-arginineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• CHEBI:16497Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by PKM, PKLRcytosol

• protein polypeptide chainReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by AGXT2cytosol, mitochondrial matrixOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space

• CHEBI:16633Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by TYW1B, TYW1, MARS1cytosol

• (R)-glycerateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by AGXT, GRHPRcytosolOne of 4 routes

• quinolinic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Transport of Quinolinic Acid

  Catalysed by SUOX, SLC22A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by TYW1B, TYW1, AADATcytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol

• CHEBI:16856Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. Persulfide dioxygenase

  Catalysed by ETHE1cytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• N-acetyl-L-aspartateReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by GOT1, SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosolOne of 2 routes

• oxalic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6cytosol, mitochondrial matrix, extracellular space

• glycolaldehydeReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space, endoplasmic reticulum

• enol-oxaloacetateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by ME2, SDHB, SDHAcytosol

• AH2Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AGXT2, MOCOScytosol, mitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Steryl-Sulfatase

  Catalysed by SUOX, STScytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AGXT2, AARS1cytosol, mitochondrial matrix

• 4-methylumbelliferyl acetateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 morecytosol, extracellular space

• urateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by LDHB, LDHAL6B, SLC22A12cytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• methylarsonous acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by TSTD1, GSTO1, GSTO2cytosol

• CHEBI:17895Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• all-trans-retinalReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by KYAT1cytosol

• CHEBI:18019Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• thiocyanateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by MPST, TSTcytosolOne of 6 routes

• 4-fumarylacetoacetateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by FAHcytosol, mitochondrial matrixOne of 2 routes

• L-glutamineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by AGXT2, SLC3A2, SLC7A5, SLC7A10cytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• dTTPReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by PKM, PKLR, ENTPD3, ENTPD1 and 1 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by AGXT2, SLC1A4cytosol, mitochondrial matrix, extracellular space

• arsenic triglutathioneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by TSTD1, AS3MTcytosolOne of 3 routes

• S-methylmercury-L-cysteineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by TYW1B, TYW1, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by AGXT2, BCKDHA, BCKDHBcytosol, mitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by TSTD1, MGST3cytosol