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Proteins/UNIPROT:O75414
Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity..
Function from UniProtKB (O75414), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
77 statements
77 statements · 7 reference databases · Subject: NME6 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
30 reactions
5 names
Resolves to: NME6
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04016CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04018CC BY 4.0Reference data
ADP+CHEBI:17677ATP+CHEBI:17239
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04028CC BY 4.0Reference data
ADP+CHEBI:17677ATP+CHEBI:17239
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04030CC BY 4.0Reference data
ADP+CHEBI:16284ATP+CHEBI:16174
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04044CC BY 4.0Reference data
ADP+CHEBI:16039ATP+CHEBI:17808
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04291CC BY 4.0Reference data
ADP+CHEBI:16284ATP+CHEBI:16174
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04420CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04570CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04572CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04635CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04670CC BY 4.0Reference data