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CompoundsSubstances with curated findings
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PathwaysReactions grouped under one name
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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Compound

2-(alpha-Hydroxypropyl)thiamine diphosphate

CHEBI:190398ChEBI

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What it touches on the way

Inferred

Not reported; assembled from reference reactions.

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

BCKDHAProteinUNIPROT:P12694substrate ofInferred only19 paths19 endpoints
BCKDHBProteinUNIPROT:P21953substrate ofInferred only16 paths16 endpoints
DBTProteinUNIPROT:P11182substrate ofInferred only1 path1 endpoint

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: 2-(alpha-Hydroxypropyl)thiamine diphosphate · Sources: Human-GEM

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2-(alpha-Hydroxypropyl)thiamine diphosphate is converted to thiamine(1+) diphosphateCompoundHuman-GEM MAR20177Inferred only
2-(alpha-Hydroxypropyl)thiamine diphosphate is a substrate of BCKDHAProteinHuman-GEM MAR20177Inferred only
2-(alpha-Hydroxypropyl)thiamine diphosphate is a substrate of BCKDHBProteinHuman-GEM MAR20177Inferred only
2-(alpha-Hydroxypropyl)thiamine diphosphate is a substrate of DBTProteinHuman-GEM MAR20177Inferred only

Reactions

2 reactions

2-oxobutanoate+proton+thiamine(1+) diphosphatecarbon dioxide+2-(alpha-Hydroxypropyl)thiamine diphosphate
Catalysed by BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4GO:0005759
Human-GEM MAR03800CC BY 4.0Reference data
MAM02393m+2-(alpha-Hydroxypropyl)thiamine diphosphatethiamine(1+) diphosphate+MAM20082m
Catalysed by DBT & BCKDHA & BCKDHB
Reaction pageLeft to rightBalance undeterminableEC 1.2.4.4GO:0005759
Human-GEM MAR20177CC BY 4.0Reference data

Other names

1 name

Resolves to: 2-(alpha-Hydroxypropyl)thiamine diphosphate

Systematic name: 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxypropyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate