3-sulfino-L-alanine

Three steps

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, PFASmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• kinetensinReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. Chymase

  Catalysed by SLC25A12, SLC25A13, SLC7A13, CMA1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 3 routes

• (7Z)-octadecenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SLC25A12, SLC25A13, NAT8L, CPT1A and 2 moremitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, NAT8L, AACSmitochondrial matrix, cytosolOne of 2 routes

• cholineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC25A12, SLC25A13, NAT8L, CHATmitochondrial matrix, cytosol, nucleus

• acetylpyruvateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by GOT1, FAHD1cytosol

• all-trans-retinoic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, PAHmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15380Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SLC25A12, SLC25A13, NAT8L, ALAS1 and 1 moremitochondrial matrix, cytosolOne of 8 routes

• CHEBI:15477Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC25A12, SLC25A13, NAT8L, GLYAT and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC25A12, SLC25A13, NAT8L, CPT1A and 1 moremitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC25A12, SLC25A13, NAT8L, HADHA and 2 moremitochondrial matrix, cytosolOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC25A12, SLC25A13, NAT8L, GLYATmitochondrial matrix, cytosol

• isovaleryl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC25A12, SLC25A13, NAT8L, GLYAT and 2 moremitochondrial matrix, cytosolOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SLC25A12, SLC25A13, NAT8L, ACAA1 and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC25A12, SLC25A13, NAT8L, CPT1A and 2 moremitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, NAT8L, ACSS3 and 2 moremitochondrial matrix, cytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. transport of D-alanine and glutamine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC3A2 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by GOT1, ME2cytosolOne of 13 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC25A12, SLC25A13, SLC7A13, PAHmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• CHEBI:15650Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC25A12, SLC25A13, NAT8L, ZDHHC11B and 31 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and homoserine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 29 routes

• CHEBI:15727Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC25A12, SLC25A13, GAD2, CARNS1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC25A12, SLC25A13, NAT8L, SAT1 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. solute carrier (L-dopa)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC3A2 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular space

• malonateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, GFPT2 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• N-acetyl-beta-D-glucosaminylamineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A12, SLC25A13, AGAmitochondrial matrix, cytosol

• thioredoxin dithiolReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SLC25A12, SLC25A13, DARS1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and histidine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 18 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GOT1, AGXT2cytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC25A12, SLC25A13, NAT8L, DGAT1 and 4 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A12, SLC25A13, AGXT2mitochondrial matrix, cytosol

• L-citrullineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by SLC25A12, SLC25A13, ASS1mitochondrial matrix, cytosolOne of 18 routes

• L-arginineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A12, SLC25A13, ASS1, ASLmitochondrial matrix, cytosolOne of 36 routes

• CHEBI:16523Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. transport of D-serine and glutamine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC3A2 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• 2-phenylacetamideReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, EPXmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:16633Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A12, SLC25A13, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, MARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• (S)-lactateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by GOT1, LDHA, LDHB, LDHC and 2 morecytosol

• quinolinic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Transport of Quinolinic Acid

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A12, SLC25A13, SLC7A13, AADATmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC25A12, SLC25A13, SLC7A13, CNDP2mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 2-oxobutanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by GOT1, AGXT2cytosol

• tryptamineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC25A12, SLC25A13, SLC7A13, DDCmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 2-oxoglutaramateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by GOT1, KYAT1cytosolOne of 5 routes

• 3-fumarylpyruvateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by GOT1, FAHD1cytosol