2-oxoglutaramate

Three steps

• CHEBI:15765Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by KYAT1, SLC7A5, THextracellular space, cytosolOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by KYAT1, CADcytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)

  Catalysed by KYAT1, GFPT2, GFPT1, GNPDA1 and 1 morecytosol

• thioredoxin dithiolReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by KYAT1, QARS1cytosolOne of 2 routes

• sulfateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by KYAT1, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by KYAT1, SLC7A9, SLC3A1cytosol, extracellular spaceOne of 9 routes

• 11-cis-retinolReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by KYAT1, DGAT1, LRAT, AWAT1 and 2 morecytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by KYAT1, AGXT2cytosol, mitochondrial matrix

• iodideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by KYAT1, SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by KYAT1, ACLYcytosolOne of 6 routes

• nitric oxideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by KYAT1, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by KYAT1, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by KYAT1, GOT2, TAT, EPXmitochondrial matrix, cytosol

• D-alanyl-D-alanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of D-alanine and glutamine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by KYAT1, SLC3A2, SLC7A10extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by KYAT1, SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by KYAT1, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by KYAT1, AADATOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by KYAT1, GOT2, TAT, CNDP2mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by KYAT1, AADAT, AGXT2One of 3 routes

• tryptamineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by KYAT1, SLC7A5, DDCextracellular space, cytosol

• CHEBI:16856Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by KYAT1, SLC7A5, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by KYAT1, SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by KYAT1, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC26A6extracellular space, cytosol

• 3-hydroxypyruvateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+)

  Catalysed by KYAT1, SLC1A5, DAOinner side of the membrane, outer side of the membrane

• L-glutamic 5-semialdehydeReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by KYAT1, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by KYAT1, NAT2, NAT1cytosol

• CHEBI:17312Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by KYAT1cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by KYAT1, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by KYAT1, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by KYAT1, SLC7A6extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYAT1, MOCOScytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by KYAT1, SLC7A5, ALAS1, ALAS2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by KYAT1, AADATOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by KYAT1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by KYAT1, AARS1cytosol

• glycine betaineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by KYAT1, SLC7A6, HALextracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by KYAT1, SLC7A5, TPH1, TPH2extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by KYAT1, AADATOne of 5 routes

• CHEBI:17927Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by KYAT1, SLC7A6, SLC3A2extracellular space, cytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by KYAT1, SLC1A4cytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Transport of 3-Ureidopropionate

  Catalysed by KYAT1, SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. phosphoribosyl pyrophosphate amidotransferase (glutamine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by KYAT1, PPAT, GARTcytosolOne of 2 routes

• 2-phenylethylamineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by KYAT1, GOT2, TAT, DDCmitochondrial matrix, cytosol

• ophthalmateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by KYAT1, SLC7A5, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by KYAT1, GOT2, TAT, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by KYAT1, SLC1A5, SLC7A10inner side of the membrane, outer side of the membrane