iodide

Three steps

• Ala-tRNA(Ala)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, AARS1extracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC26A4, SLC6A14, HALextracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC26A4, SLC6A14, TPH1, TPH2extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC26A4, SLC6A14, SLC3A2, SLC7A6extracellular space, cytosol

• 3-oxopropanoic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A6, SLC6A14, ABATextracellular space, cytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC26A4, SLC6A14, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by SLC26A4, SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC26A4, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC26A4, SLC5A7, CHKA, CHKBextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC26A4, SLC6A14, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC26A4, SLC6A14, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by SLC26A4, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC26A4, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by DIO1, DIO2, DIO3cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC26A4, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC26A4, SLC6A14, CARS2extracellular space, cytosol

• 3-iodo-L-thyronineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by DIO1, DIO3, DIO2cytosol

• 3'-iodo-L-thyronineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by DIO1, DIO3, DIO2cytosol

• alpha-linolenic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC26A4, SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATextracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC26A4, SLC6A14, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 10 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 5 routes

• pyridoxine 5'-phosphateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC26A4, SLC6A14, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC26A4, SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A35, SLC25A34extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC26A4, SLC6A14, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC26A4, SLC12A2, SLC12A1, SLC24A1 and 4 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GARS1extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, QARS1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC26A4, SLC6A14, NARS1extracellular space, cytosol

• phosphocholineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC26A4, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 7 routes

• cholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• hydrogen sulfideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC26A4, SLC6A14, CTHextracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC25A30extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC12A2, SLC12A1, SLC1A7 and 4 moreextracellular space, cytosolOne of 22 routes

• acetateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1extracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC26A4, SLC6A14, IDO1, TDO2 and 1 moreextracellular space, cytosol

• oxalateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC26A4, SLC26A6, SLC25A14, SLC26A2 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• propionic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1extracellular space, cytosolOne of 2 routes