Compound
5(S)-HETE
A HETE having a (5S)-hydroxy group and (6E)-, (8Z)-, (11Z)- and (14Z)-double bonds.
Definition from ChEBI (CHEBI:28209), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
10 entities
10 entities reached.
0 reported hops10 assembled from the scaffold
- ALOX5ProteinUNIPROT:P09917substrate ofInferred only110 paths55 endpoints
- ALOX12ProteinUNIPROT:P18054substrate ofInferred only84 paths28 endpoints
- CYP4F2ProteinUNIPROT:P78329metabolized byInferred only36 paths18 endpoints
- CYP4F22ProteinUNIPROT:Q6NT55metabolized byInferred only34 paths17 endpoints
- CYP4F3ProteinUNIPROT:Q08477metabolized byInferred only32 paths16 endpoints
- CBR1ProteinUNIPROT:P16152substrate ofInferred only22 paths22 endpoints
- DHRS4ProteinUNIPROT:Q9BTZ2substrate ofInferred only21 paths7 endpoints
- CYP4F11ProteinUNIPROT:Q9HBI6metabolized byInferred only13 paths13 endpoints
- CYP4F8ProteinUNIPROT:P98187metabolized byInferred only13 paths13 endpoints
- CBR3ProteinUNIPROT:O75828substrate ofInferred only9 paths9 endpoints
What the reference databases state
Statements
18 statements
18 statements · 1 reference database · Subject: 5(S)-HETE · Sources: Human-GEM
- 5(S)-HETE is metabolised by CYP4F11ProteinHuman-GEM MAR00969Inferred only
- 5(S)-HETE is metabolised by CYP4F2ProteinHuman-GEM MAR00969Inferred only
- 5(S)-HETE is metabolised by CYP4F2ProteinHuman-GEM MAR03891Inferred only
- 5(S)-HETE is metabolised by CYP4F22ProteinHuman-GEM MAR03891Inferred only
- 5(S)-HETE is metabolised by CYP4F22ProteinHuman-GEM MAR00969Inferred only
- 5(S)-HETE is metabolised by CYP4F3ProteinHuman-GEM MAR00969Inferred only
- 5(S)-HETE is metabolised by CYP4F3ProteinHuman-GEM MAR03891Inferred only
- 5(S)-HETE is metabolised by CYP4F8ProteinHuman-GEM MAR00969Inferred only
- 5(S)-HETE is a substrate of ALOX12ProteinHuman-GEM MAR00961Inferred only
- 5(S)-HETE is a substrate of ALOX12ProteinHuman-GEM MAR00964Inferred only
- 5(S)-HETE is a substrate of ALOX12ProteinHuman-GEM MAR00967Inferred only
- 5(S)-HETE is a substrate of ALOX5ProteinHuman-GEM MAR00971Inferred only
Show the remaining 6
- 5(S)-HETE is a substrate of ALOX5ProteinHuman-GEM MAR03893Inferred only
- 5(S)-HETE is a substrate of CBR1ProteinHuman-GEM MAR00973Inferred only
- 5(S)-HETE is a substrate of CBR3ProteinHuman-GEM MAR00973Inferred only
- 5(S)-HETE is a substrate of DHRS4ProteinHuman-GEM MAR00973Inferred only
- 5(S)-HETE is a substrate of DHRS4ProteinHuman-GEM MAR03894Inferred only
- 5(S)-HETE is a substrate of DHRS4ProteinHuman-GEM MAR03896Inferred only
Reactions
18 reactions
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR00960CC BY 4.0Reference data
5(S)-HETE+2proton+dioxygenwater+MAM02364c
Catalysed by ALOX12
Reaction pageLeft to rightUnbalancedEC 1.13.11.31cytosol
Human-GEM MAR00961CC BY 4.0Reference data
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9mitochondrial matrix
Human-GEM MAR00963CC BY 4.0Reference data
5(S)-HETE+2proton+dioxygenwater+MAM02364m
Catalysed by ALOX12
Reaction pageLeft to rightUnbalancedEC 1.13.11.31mitochondrial matrix
Human-GEM MAR00964CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, endoplasmic reticulum
Human-GEM MAR00966CC BY 4.0Reference data
5(S)-HETE+2proton+dioxygenwater+MAM02364r
Catalysed by ALOX12
Reaction pageLeft to rightUnbalancedEC 1.13.11.31endoplasmic reticulum
Human-GEM MAR00967CC BY 4.0Reference data
5(S)-HETE+proton+NADPH(4-)+dioxygenMAM00590c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR00969CC BY 4.0Reference data
5(S)-HETE+2proton+dioxygenMAM01050c+water
Catalysed by ALOX5
Reaction pageLeft to rightUnbalancedEC 1.13.11.34cytosol
Human-GEM MAR00971CC BY 4.0Reference data
5(S)-HETE+NADP(3-)MAM01126c+proton+NADPH(4-)
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.184cytosol
Human-GEM MAR00973CC BY 4.0Reference data
5(S)-HETE+proton+NADPH(4-)+dioxygenMAM00590r+water+NADP(3-)
Catalysed by CYP4F22 or CYP4F2 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR03891CC BY 4.0Reference data
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34nucleus
Human-GEM MAR03893CC BY 4.0Reference data
5(S)-HETE+NADP(3-)MAM01126m+proton+NADPH(4-)
Catalysed by DHRS4
Reaction pageReversibleBalancedEC 1.1.1.184mitochondrial matrix
Human-GEM MAR03894CC BY 4.0Reference data
Other names
9 names
Resolves to: 5(S)-HETE
- Also called
- (5S,6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid(6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid(S)-(E,Z,Z,Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid5-Hydroxyeicosatetraenoate5(S)-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid5(S)-hydroxyeicosatetraenoic acid5S-HETE6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-
- Systematic name
- (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid