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Proteins/UNIPROT:O60721
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation..
Function from UniProtKB (O60721), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
2 rows
54 statements
54 statements · 5 reference databases · Subject: SLC24A1 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
4 reactions
Ca(2+)+4sodium(1+)+ammoniumCa(2+)+4sodium(1+)+ammonium
Transported by SLC24A1 or SLC24A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01529CC BY 4.0Reference data
5 names
Resolves to: SLC24A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07631CC BY 4.0Reference data
Ca(2+)+4sodium(1+)+ammoniumCa(2+)+4sodium(1+)+ammonium
Transported by SLC24A1 or SLC24A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07632CC BY 4.0Reference data
Ca(2+)+K(+)+4sodium(1+)Ca(2+)+K(+)+4sodium(1+)
Transported by SLC24A1 or SLC24A5 or SLC24A4 or SLC24A3 or SLC24A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:69967CC BY 4.0Reference data