trimethylenediamine

Three steps

• hypochlorous acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by DHPS, SLC6A14, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by DHPS, SLC6A14, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 2 routes

• phenylacetylglycineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by DHPS, SLC7A6, GLYATcytosol, extracellular spaceOne of 3 routes

• CHEBI:27540Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by DHPS, ACSM4, ACSM1, ACSM2A and 3 morecytosol, mitochondrial matrixOne of 6 routes

• elaidic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by DHPS, SLC7A6, TPH1, TPH2cytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by DHPS, SLC7A6cytosol, extracellular space

• CHEBI:28701Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by DHPS, ACAA1, SCP2, MYO5Bcytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by DHPS, SLC7A6, SCLYcytosol, extracellular space

• N-acetyl-L-cysteineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DHPS, SLC7A6, NAGScytosol, extracellular space, mitochondrial matrix

• K(+)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by DHPS, SLC7A6, SLC1A1cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, CARS1cytosol, extracellular space

• Phe-tRNA(Phe)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, FARSB, FARSAcytosol, extracellular space

• Gly-tRNA(Gly)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, GARS1cytosol, extracellular space

• Trp-tRNA(Trp)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, WARS1cytosol, extracellular space

• Ile-tRNA(Ile)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of isoleucine and lysine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, IARS1cytosol, extracellular space

• Gln-tRNA(Gln)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, QARS1cytosol, extracellular space

• isocyanateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of citrulline and lysine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by DHPS, SLC7A5, SLC7A6, LACC1cytosol, extracellular space

• Asn-tRNA(Asn)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of asparagine and lysine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by DHPS, SLC7A6, NARS1cytosol, extracellular space

• glycocholateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DHPS, SLC7A6, BAATcytosol, extracellular space, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by DHPS, SLC7A6, CTHcytosol, extracellular spaceOne of 2 routes

• L-aspartateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by DHPS, SLC7A6, AGXT2cytosol, extracellular spaceOne of 19 routes

• acetateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. N8-acetylspermidine to spermidine conversion
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by DHPS, HDAC10cytosol

• CHEBI:30249Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by DHPS, SLC7A6, IDO1, TDO2 and 1 morecytosol, extracellular space

• 3-acetamidopropanalReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by DHPS, SAT1, SAT2, PAOX and 1 morecytosolOne of 4 routes

• formic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by DHPS, SLC6A14, SLC26A4cytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by DHPS, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-lysineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by DHPS, SLC7A5, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-arginineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by DHPS, SLC7A5, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. primary-amine oxidase (1,3-diaminopropane)
  2. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by AOC2, AOC1, AOC3, ALDH2 and 2 morecytosol, mitochondrial matrix

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by DHPS, SLC7A6, IL4I1cytosol, extracellular space

• di-mu-sulfido-diiron(2+)Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by DHPS, SLC7A6, NDUFAB1, FDXR and 5 morecytosol, extracellular space, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of isoleucine and lysine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by DHPS, SLC7A6, BCAT2, BCAT1cytosol, extracellular space

• D-cysteineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by DHPS, SLC7A6, ALAS1, ALAS2cytosol, extracellular space

• 3-methyl-2-oxovaleric acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of isoleucine and lysine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by DHPS, SLC7A6, BCAT1cytosol, extracellular spaceOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by DHPS, SLC7A6, GOT2, GOT1 and 1 morecytosol, extracellular spaceOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by DHPS, SLC7A6, BAATcytosol, extracellular space

• glycochenodeoxycholic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DHPS, SLC7A6, BAATcytosol, extracellular space, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by DHPS, SLC7A6, AADATcytosol, extracellular spaceOne of 11 routes

• glycolithocholic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by DHPS, SLC7A6, BAATcytosol, extracellular spaceOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by DHPS, SLC7A6, GCATcytosol, extracellular space, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by DHPS, SLC7A6, GGT1, GGT5 and 4 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by DHPS, SLC7A6, GLDC, GCSHcytosol, extracellular space, mitochondrial matrix

• taurineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of chloride and lysine (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by DHPS, SLC6A14, SLC6A6cytosol, extracellular spaceOne of 4 routes

• (R)-methylmalonyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by DHPS, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by DHPScytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by DHPS, ACP2cytosol, mitochondrial matrix, lysosomeOne of 2 routes