Compound
CHEBI:27540
A medium-chain fatty acyl-CoA having hexanoyl as the S-acyl group.
Definition from ChEBI (CHEBI:27540), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- ACOX1ProteinUNIPROT:Q15067substrate ofInferred only45 paths15 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- HSD17B4ProteinUNIPROT:P51659substrate ofInferred only27 paths27 endpoints
- ACAA1ProteinUNIPROT:P09110substrate ofInferred only24 paths24 endpoints
- ACOX3ProteinUNIPROT:O15254substrate ofInferred only22 paths11 endpoints
- EHHADHProteinUNIPROT:Q08426substrate ofInferred only21 paths21 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- GLYATProteinUNIPROT:Q6IB77substrate ofInferred only15 paths15 endpoints
- ACADSBProteinUNIPROT:P45954substrate ofInferred only10 paths10 endpoints
- DBIProteinUNIPROT:P07108transported byInferred only9 paths9 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- CROTProteinUNIPROT:Q9UKG9substrate ofInferred only7 paths7 endpoints
What the reference databases state
Statements
27 statements
27 statements · 1 reference database · Subject: CHEBI:27540 · Sources: Human-GEM
- (2E)-hexenoyl-CoA is converted to CHEBI:27540CompoundHuman-GEM MAR02207Inferred only
- CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR02207Inferred only
- CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR03156Inferred only
- CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR03098Inferred only
- CHEBI:1146900 is converted to CHEBI:27540CompoundHuman-GEM MAR00168Inferred only
- CHEBI:27540 is converted to CHEBI:1146900CompoundHuman-GEM MAR10377Inferred only
- CHEBI:27540 is converted to CHEBI:1146900CompoundHuman-GEM MAR10374Inferred only
- CHEBI:27540 is converted to CHEBI:1146900CompoundHuman-GEM MAR11544Inferred only
- CHEBI:27540 is a substrate of ACAA1ProteinHuman-GEM MAR06284Inferred only
- CHEBI:27540 is a substrate of ACADSBProteinHuman-GEM MAR03156Inferred only
- CHEBI:27540 is a substrate of ACOT12ProteinHuman-GEM MAR11544Inferred only
- CHEBI:27540 is a substrate of ACOT8ProteinHuman-GEM MAR10377Inferred only
Show the remaining 15
- CHEBI:27540 is a substrate of ACOT9ProteinHuman-GEM MAR10374Inferred only
- CHEBI:27540 is a substrate of ACOX1ProteinHuman-GEM MAR06284Inferred only
- CHEBI:27540 is a substrate of ACOX1ProteinHuman-GEM MAR03156Inferred only
- CHEBI:27540 is a substrate of ACOX1ProteinHuman-GEM MAR03098Inferred only
- CHEBI:27540 is a substrate of ACOX3ProteinHuman-GEM MAR03098Inferred only
- CHEBI:27540 is a substrate of ACOX3ProteinHuman-GEM MAR03156Inferred only
- CHEBI:27540 is a substrate of CPT1AProteinHuman-GEM MAR04719Inferred only
- CHEBI:27540 is a substrate of CPT1BProteinHuman-GEM MAR04719Inferred only
- CHEBI:27540 is a substrate of CPT1CProteinHuman-GEM MAR04719Inferred only
- CHEBI:27540 is a substrate of CROTProteinHuman-GEM MAR04722Inferred only
- CHEBI:27540 is a substrate of EHHADHProteinHuman-GEM MAR06284Inferred only
- CHEBI:27540 is a substrate of GLYATProteinHuman-GEM MAR11555Inferred only
- CHEBI:27540 is a substrate of HSD17B4ProteinHuman-GEM MAR06284Inferred only
- CHEBI:27540 is a substrate of MECRProteinHuman-GEM MAR02207Inferred only
- CHEBI:27540 is transported by DBIProteinHuman-GEM MAR00169Inferred only
Reactions
18 reactions
ATP+CHEBI:1146900+MAM02120cAMP+CHEBI:27540+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2GO:0005829
Human-GEM MAR00168CC BY 4.0Reference data
Transported by DBI
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR00169CC BY 4.0Reference data
(2E)-hexenoyl-CoA+proton+NADPH(4-)CHEBI:27540+NADP(3-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38GO:0005759
Human-GEM MAR02207CC BY 4.0Reference data
3-oxooctanoyl-CoA+CHEBI:1146900CHEBI:15351+CHEBI:27540
Reaction pageLeft to rightBalancedEC 2.3.1.16GO:0005777
Human-GEM MAR03097CC BY 4.0Reference data
FAD+CHEBI:27540(2E)-hexenoyl-CoA+FADH2
Reaction pageLeft to rightBalancedEC 1.3.3.6GO:0005777
Human-GEM MAR03098CC BY 4.0Reference data
3-oxooctanoyl-CoA+CHEBI:1146900CHEBI:15351+CHEBI:27540
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211GO:0005759
Human-GEM MAR03153CC BY 4.0Reference data
FAD+CHEBI:27540(2E)-hexenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1 or ACADSB
Reaction pageLeft to rightBalancedEC 1.3.8.5, 1.3.3.6GO:0005759
Human-GEM MAR03156CC BY 4.0Reference data
CHEBI:27540+(S)-carnitineCHEBI:1146900+MAM03498c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21GO:0005829
Human-GEM MAR04719CC BY 4.0Reference data
CHEBI:27540+(S)-carnitineCHEBI:1146900+MAM03498x
Catalysed by CROT
Reaction pageReversibleBalancedGO:0005777
Human-GEM MAR04722CC BY 4.0Reference data
CHEBI:1146900+FAD+water+CHEBI:27540+NAD(+)CHEBI:15351+butanoyl-CoA+FADH2+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR06284CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+octanoyl-CoACHEBI:15351+FADH2+proton+CHEBI:27540+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR06344CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR10250CC BY 4.0Reference data
Other names
10 names
Resolves to: CHEBI:27540
- Also called
- caproyl-CoAcaproyl-coenzyme ACoenzyme A, S-hexanoateHexanoyl-CoAHexanoyl-coenzyme An-hexanoyl-CoAn-hexanoyl-coenzyme AS-hexanoyl-CoAS-hexanoyl-coenzyme-A
- Systematic name
- 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-4-[(3-{[2-(hexanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl} dihydrogen diphosphate)