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Proteins/UNIPROT:Q16853
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion..
[Isoform 2]: Has no semicarbazide-sensitive amine oxidase (SSAO) activity..
Function from UniProtKB (Q16853), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
217 statements
217 statements · 8 reference databases · Subject: AOC3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
32 reactions
MAM01332c+water+dioxygenproton+hydrogen peroxide+methylglyoxal+ammonium
Catalysed by AOC3
Reaction pageLeft to rightBalancedEC 1.4.3.21cytosol
Human-GEM MAR03852CC BY 4.0Reference data
8 names
Resolves to: AOC3
Reaction pageLeft to rightBalancedEC 1.4.3.10, 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR04423CC BY 4.0Reference data
water+N(tau)-methylhistamine+dioxygenproton+hydrogen peroxide+1-methylimidazole-4-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04430CC BY 4.0Reference data
water+dioxygen+2-phenylethylamineproton+hydrogen peroxide+ammonium+2-phenylacetaldehyde
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR04682CC BY 4.0Reference data
dopamine+water+dioxygen3,4-dihydroxyphenylacetaldehyde+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06758CC BY 4.0Reference data
water+dioxygen+MAM03099cMAM01002c+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR06789CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06931CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR06932CC BY 4.0Reference data
FAD+water+CHEBI:15746FADH2+proton+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22peroxisome
Human-GEM MAR06933CC BY 4.0Reference data
water+dioxygen+spermine monoaldehydeproton+hydrogen peroxide+ammonium+MAM02924c
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06934CC BY 4.0Reference data
water+dioxygen+spermine monoaldehydeproton+hydrogen peroxide+ammonium+MAM02924e
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR06935CC BY 4.0Reference data
FAD+water+spermine monoaldehydeFADH2+proton+ammonium+MAM02924x
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22peroxisome
Human-GEM MAR06936CC BY 4.0Reference data